血糖波动与2型糖尿病合并细菌性肝脓肿的相关性分析  

Correlations between glucose fluctuation and type 2 diabetes mellitus with bacterial liver abscess

作　　者：徐志刚[1] 陈小罗[1] 吴艳[1] 王丽[1] 姜惠[1] 吴晨光[1] XU Zhi-gang(Department of endocrinology,people's hospital affiliated to Jiangsu University,Zhenjiang,Jiangsu,212002, China)

机构地区：[1]江苏大学附属人民医院内分泌科

出　　处：《齐齐哈尔医学院学报》2019年第13期1640-1642,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨血糖波动与2型糖尿病合并细菌性肝脓肿的相关性分析。方法回顾性分析2013年1月—2017年12月于江苏大学附属人民医院内分泌科住院的22例2型糖尿病合并细菌性肝脓肿患者在入院后头24小时7次血糖的标准差(SDBG),剔除1例自动出院患者。根据其分布情况将21例患者分为SDBG≤3.75组(A组,n=11)和SDBG>3.75组(B组,n=10)两组,独立样本t检验分析比较两组间性别、年龄、住院时间、糖化血红蛋白、C反应蛋白、中性粒细胞计数等指标的差异;Spearman相关系数用来比较不同变量间的相关性。在相关分析后,对各变量进行逐步多元线性回归,发现影响血糖波动的因素。结果血糖波动较大组比血糖波动较小组住院时间更长、C反应蛋白、中性粒细胞计数、肌酐、尿素氮更高,两组间存在统计学差异(P<0.05)。Spearman相关分析提示SDBG与住院时间、中性粒细胞比例、C反应蛋白、肌酐、尿素氮相关;多元线性回归分析提示住院时间、C反应蛋白与SDBG增加呈正相关。结论对于平时血糖控制差的2型糖尿病合并肝脓肿时,血糖波动增大。血糖波动延长2型糖尿病合并肝脓肿住院时间。Objective To evaluate the correlations between glycemic variability and type 2 diabetes mellitus with bacterial liver abscess. Methods 22 cases of type 2 diabetes mellitus with bacterial liver abscess patients,hospitalized in endocrinology department of the people's hospital affiliated to Jiangsu University during January 2013 and December 2017,were collected.According to standard deviation of blood glucose( SDBG) in the first 24 hours after admission( 7 times of determination),the patients were divided into two groups( SDBG≤3.75 and SDBG>3.75).Independent t-test analysis was used to compare the differences of age,gender,hospitalization time,glycosylated hemoglobin,c-reactive protein,and neutrophil count between the two groups. Spearman correlation coefficient was used to compare the correlation between different variables. After correlation analysis,the variables were leaded into a gradual multivariate linear regression model to extract the factors influencing the glycemic variability. Results Compared with the group of lower glycemic fluctuation,hospitalization time was longer in the group of higher glycemic fluctuation,and c-reactive protein,neutrophil count,creatinine,urea nitrogen increased significantly(P<0.05).Spearman correlation coefficient indicated that SDBG was related to hospital stay,ratio of neutrophil,c-reactive protein,creatinine,and urea nitrogen. Multivariate linear regression analysis suggested a positive correlation between hospitalization time,c-reactive protein and SDBG increase.Conclusions For the patients with poor glucose control and hepatic abscess,the blood glucose fluctuation increases.The glucose fluctuation extends the hospitalization time of type 2 diabetes with hepatic abscess.

关 键 词：血糖波动 2型糖尿病 细菌性肝脓肿 

分 类 号：R587.1[医药卫生—内分泌]