异常原核数来源胚胎的妊娠结局分析  

Analysis of pregnancy outcome of embryos derived from abnormal prokaryotes

作　　者：张旸[1] 翟妍[2] 付磊[1] 李媛[1] Zhang Yang;Zhai Yan;Fu Lei;Li Yuan(Reproductive Center, Beijing Chaoyang Hospital Affiliated to Beijing Capital Medical University, Beijing 100020, China;Department of Gynecology and Obstetrics, Beijing Chaoyang Hospital Affiliated to Beijing Capital Medical University, Beijing 100020, China)

机构地区：[1]首都医科大学附属北京朝阳医院生殖中心,北京100020 [2]首都医科大学附属北京朝阳医院妇产科,北京100020

出　　处：《中华医学杂志》2019年第29期2308-2310,共3页National Medical Journal of China

摘　　要：目的总结移植异常原核数[0PN(non-pronuclear)、1PN(one-pronuclear)]来源胚胎病例的临床结局,以供临床工作中参考。方法收集2013年1月1日至2018年12月31日期间于首都医科大学附属北京朝阳医院生殖中心接受体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI -ET)助孕的不孕症患者的临床资料,进行回顾性分析移植0PN、1PN来源胚胎病例的妊娠结局。结果总结了47例患者,移植非2PN来源胚胎50个周期。只移植0PN有18个周期,临床妊娠率50.0%。只移植1PN有17个周期,临床妊娠率29.4%,与0PN比较,差异无统计学意义(P>0.05)。已分娩的新生儿未见异常。结论在没有2个原核(2PN)来源的胚胎可以移植的情况下,患者可以移植0PN与1PN来源的囊胚,可以获得可接受的临床妊娠结局,0PN的临床结局可能更好。Objective To summarize the clinical outcome of abnormal prokaryotic embryos [OPN (non-pronuclear), 1PN (one-pronuclear)] transfer for reference in clinical work. Methods To collect the clinical data of infertility patients who received in vitro fertilization/intracytoplasmic sperm microinjection-embryo transfer from January 1, 2013 to December 31, 2018 at the reproductive center of Beijing Chaoyang Hospital Affiliated to Capital Medical University, and to retrospectively analyze the pregnancy outcome of the cases of embryo transfer from 0PN and 1PN sources. Results Forty-seven patients were transplanted non-2PN-derived embryos during 50 cycles. There were 18 cycles which only 0PN embryos were transplanted, and the clinical pregnancy rate was 50.0%. There were 17 cycles which only 1PN embryos were transplanted, and the clinical pregnancy rate was 29.4%(compared with 0PN, the difference was not statistically significant, P>0.05). No abnormalities were found in the delivered newborns. Conclusions In the absence of 2PN-derived embryos, patients can be transplanted blastocysts from 0PN and 1PN sources. Acceptable clinical pregnancy outcomes can be achieved, and the clinical outcomes of 0PN may be better than 1PN.

关 键 词：体外受精 胚胎移植 异常原核 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]