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作 者:赵科超 王晓君 陈维毅 贺瑞[3] 李晓娜 高妍[3] ZHAO Kechao;WANG Xiaojun;CH ENWeiyi;HE Rui;LI Xiaona;GAO Yan(School of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China;School of Mechanical and Transportation Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China;Department ofExcimer Laser, Shanxi Eye Hospital, Taiyuan 030002, P.R.China)
机构地区:[1]太原理工大学生物医学工程学院,太原030024 [2]太原理工大学机械与运载工程学院,太原030024 [3]山西省眼科医院准分子激光科,太原030002
出 处:《生物医学工程学杂志》2019年第4期613-618,共6页Journal of Biomedical Engineering
基 金:国家自然科学基金资助项目(11402161,11872262);山西省重点研发计划项目(201703D421019);山西省卫生计生委科研课题资助项目(2017099)
摘 要:研究在体角膜材料的力学特性,是进一步借助有限元方法研究角膜生理与病理现象的重要基础。本文借助可视化角膜生物力学分析仪所提供的数据,使用标准线性固体模型计算正常角膜和圆锥角膜在脉冲气压作用下的弹性系数(E)和粘性系数(η)。研究发现,正常角膜和圆锥角膜的E与η之间的差异具有统计学意义(P <0.05)。受试者工作特征曲线分析发现,E、η及其联合指标的曲线下面积(AUC)分别为0.776、0.895、0.948,说明该指标可以对圆锥角膜进行较好的预测。本文研究结果或可为圆锥角膜的早期诊断提供参考,以避免术后圆锥角膜的发生,因此具有一定的临床实用价值。Study of the mechanical properties of in vivo corneal materials is an important basis for further study of corneal physiological and pathological phenomena by means of finite element method. In this paper, the elastic coefficient (E) and viscous coefficient (η) of normal cornea and keratoconus under pulse pressure are calculated by using standard linear solid model with the data provided by corneal visualization scheimpflug technology. The results showed that there was a significant difference of E and η between normal cornea and keratoconus cornea (P < 0.05). Receiver operating characteristic curve analysis showed that the area under curve (AUC) for E,η and their combined indicators were 0.776, 0.895 and 0.948, respectively, which indicated that keratoconus could be predicted by E and η. The results of this study may provide a reference for the early diagnosis of keratoconus and avoid the occurrence of keratoconus after operation, so it has a certain clinical value.
关 键 词:可视化角膜生物力学分析仪 标准线性固体模型 弹性系数 粘性系数 圆锥角膜
分 类 号:R318.08[医药卫生—生物医学工程]
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