硫普罗宁注射液联合恩替卡韦对肺结核合并慢性乙肝患者临床治疗效果  

Clinical effect of tiopronin injection combined with entecavir on patients with pulmonary tuberculosis complicated with chronic hepatitis B

作　　者：周外民 赵富明 ZHOU Waimin;ZHAO Fuming(Tuberculosis Department,The First Hospital of Changsha,Changsha 410005,China;Department of Medicine,Hunan Chest Hospital,Changsha 410013,China)

机构地区：[1]长沙市第一医院结核科,长沙410005 [2]湖南省胸科医院内二科

出　　处：《公共卫生与预防医学》2019年第4期124-127,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的研究硫普罗宁注射液联合恩替卡韦治疗肺结核合并慢性乙肝的临床效果。方法将在长沙市第一医院进行治疗的肺结核合并慢性乙肝的患者分为硫普罗宁组和双药联合组,给予硫普罗宁组硫普罗宁注射液治疗,双药联合组使用硫普罗宁注射液和恩替卡韦片联合治疗,比较两组患者临床症状消退时间,对两组患者治疗前后的Ⅲ型前胶原(PCⅢ)、IV型胶原(Ⅳ-C)、透明质酸酶(HA)、层粘连蛋白(LN)、纤维连接蛋白(FN)水平以及肝功能指标进行检测,并统计两组患者的治疗效果及不良反应发生率。结果双药联合组患者临床症状消退时间均显著短于硫普罗宁组(P<0.05);双药联合组患者治疗后PCⅢ、Ⅳ-C、HA、LN、FN以及肝功能指标水平改善情况明显优于硫普罗宁组(P<0.05);双药联合组患者治疗总有效率高于硫普罗宁组,不良反应发生率低于硫普罗宁组(P<0.05)。结论硫普罗宁注射液联合恩替卡韦能够有效改善肺结核合并慢性乙肝患者血清纤维化及肝功能指标水平,治疗效果显著且安全性较高。Objective To study the clinical effect of tiopronin injection combined with entecavir in the treatment of pulmonary tuberculosis complicated with chronic hepatitis B. Methods Patients with pulmonary tuberculosis complicated with chronic hepatitis B treated in the First Hospital of Changsha were divided into two groups: tiopronin group and double-drug combination group. Tiopronin group was treated with tiopronin injection, and the combination group was treated with tiopronin injection and entecavir tablets. The clinical symptoms of the two groups were compared. The type III procollagen (PCIII), type IV collagen (IV-C), hyaluronidase (HA), laminin (LN), fibronectin (FN) levels, and liver function indicators before and after treatment in both groups were detected and compared. The therapeutic effects and adverse reactions of the two groups were statistically analyzed. Results The regression time of clinical symptoms of the two-drug combination group was significantly shorter than that of the tiopronin group ( P <0.05);the improvement of PCIII, IV-C, HA, LN, FN and liver function indexes of the two-drug combination group was significantly better than that of the tiopronin group ( P <0.05). The total effective rate of the two-drug combination group was higher than that of tiopronin group, and the incidence of adverse reactions was lower than that of tiopronin group ( P <0.05). Conclusion Tiopronin injection combined with entecavir can effectively improve the serum fibrosis and liver function in patients with pulmonary tuberculosis complicated with chronic hepatitis B. The therapeutic effect is significant and safe.

关 键 词：硫普罗宁注射液 恩替卡韦 肺结核合并慢性乙肝 血清纤维化 

分 类 号：R183.3[医药卫生—流行病学]