Amberlyst-15催化下的二氢[1,2,4]三唑并[1,5-a]嘧啶类及二氢苯并[4,5]咪唑并[1,2-a]嘧啶类衍生物的一锅法合成  

One-Pot Synthesis of Dihydro[1,2,4]triazolo[1,5-a]pyrimidines and Dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine Derivatives Catalyzed by Amberlyst-15

作　　者：马会芳 李文博[1] 阿布拉江·克依木[1] Ma Huifang;Li Wenbo;Ablajan Keyume(Key Laboratory of Oil & Gas Fine Chemicals,Ministry of Education & Xinjiang Uyghur Autonomous Region,College of Chemistry and Chemical Engineering,Xinjiang University,Urumqi 830046)

机构地区：[1]新疆大学化学化工学院石油天然气精细化工教育部&新疆维吾尔自治区重点实验室

出　　处：《有机化学》2019年第7期1945-1952,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21462041)资助项目~~

摘　　要：在固体酸性离子交换树脂Amberlyst-15的催化作用下,以乙醇作为溶剂,以芳香醛、β-酮酸酯、3-氨基-1,2,4-三唑或者2-氨基苯并咪唑为原料经过三组分一锅法反应合成了一系列三唑并[1,5-a]嘧啶衍生物5a^5m及二氢苯并[4,5]咪唑并[1,2-a]嘧啶类衍生物6a^6g.该方法简单高效、具有反应时间短、后处理简单、底物适用范围较广以及催化剂可以循环利用4次催化活性无明显下降的优点,符合绿色化学的基本标准.Under the catalysis of solid acidic ion exchange resin Amberlyst-15,using ethanol as solvent,aromatic aldehyde,β-ketoester,and 3-amino-1,2,4-triazole or 2-aminobenzo as starting materials,a series of triazolo[1,5-a]pyrimidine derivatives 5a^5m and dihydrobenzo[4,5]imidazo[1,2-a]pyrimidines 6a^6g were synthesized by three-component one-pot reaction of imidazole derivatives.The method is simple and efficient,and has short reaction time,simple post-treatment and wide application range of the substrate.The catalyst can be recycled for 4 times without the significant decrease of catalytic activity.It conforms to the basic standard of green chemistry.

关 键 词：二氢嘧啶衍生物 固体酸性离子交换树脂Amberlyst-15 一锅法反应 

分 类 号：O626[理学—有机化学]