通过[2,3]-Wittig重排合成烯丙基-甲基-N-泛酸酰胺（英文）  

A Synthetic Route to Access Allyl-methyl-N-pantothenamide via [2,3]-Wittig Rearrangement

作　　者：夏礼文 赵青 巴梦雨 胡超平 孙默然[1,2] 杨华 Xia Liwen;Zhao Qing;Ba Mengyu;Hu chaoping;Sun Moran;Yang Hua(School of Pharmaceutical Science,Zhengzhou University,Zhengzhou 450001;Collaborative Innovation Center of New Drug Research and Safety Evaluation,Zhengzhou 450001)

机构地区：[1]郑州大学药学院,郑州450001 [2]新药创制与药物安全性评价河南省协同创新中心,郑州450001

出　　处：《有机化学》2019年第7期2035-2041,共7页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(Nos.21372205,21302175);the Basic Research Project of Science and Technology Department of Henan Province(No.132300410028)~~

摘　　要：甲基-烯丙基-N-泛酸酰胺(1)具有手性季碳和邻位仲醇结构片段的抗菌剂,可以巧妙通过[2,3]-Wittig重排和钯催化的甲酸还原构建了其分子骨架,以10步反应制备了1.The synthetic route of allyl-methyl-N-pantothenamide(1)featuring[2,3]-Wittig rearrangement and palladium catalyzed formate reduction to assemble the requisite quaternary carbon with adjacent secondary alcohol has been reported.Our strategy presents a facile synthetic route to access 1 in 10 steps,which also provide a novel inspiration to construct chiral quaternary carbon via asymmetrical[2,3]-Wittig rearrangement.

关 键 词：[2 3]-Wittig重排 N-Pantothenamide 手性季碳 抗菌剂 

分 类 号：O623.626[理学—有机化学]