放射性粒子植入治疗早期不可手术非小细胞肺癌的临床研究  

Clinical study of radioactive particles in the treatment of inoperable early-stage non-small cell lung cancer

作　　者：付伟[1] 陈士新[1] 周庆元[2] 陈青娟 张消 赵志友 王建庄 FU Wei;CHEN Shixin;ZHOU Qingyuan;CHEN Qingjuan;ZHANG Xiao;ZHAO Zhiyou;WANG Jianzhuang(Department of Interventional Radiology,the 3201 Hospital Affiliated of Xi'an Jiaotong University , Hanzhong 723000,China;Department of Respiratory Medicine ,the 3201 Hospital Affiliated of Xi'an Jiaotong University , Hanzhong 723000,China;Department of Oncology ,Xianyang Central Hospital ,Xianyang 712000 9China)

机构地区：[1]西安交通大学附属三二0一医院介入科,陕西汉中723000 [2]西安交通大学附属三二0一医院呼吸内科,陕西汉中723000 [3]咸阳市中心医院肿瘤内科,陕西咸阳712000

出　　处：《实用放射学杂志》2019年第8期1311-1314,1318,共5页Journal of Practical Radiology

摘　　要：目的研究CT引导下放射性粒子治疗早期不可手术性非小细胞肺癌(NSCLC)的临床效果。方法选择2013年9月至2016年10月接受治疗的不可手术性NSCLC患者49例进行研究。根据数字法随机分成观察组25例以及对照组24例,对照组给予紫杉醇和顺铂的化疗方案,观察组给予CT引导下125I放射性粒子治疗,随访2年后对比近期疗效,1~2年肿瘤局部控制率和生存率,以及不良反应情况。结果观察组的近期总有效率为64.00%,与对照组的58.33%相比,差异无统计学意义(P>0.05)。观察组2年局部控制率和2年生存率均分别明显高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应的总发生率为36.00%,与对照组的41.67%相比,差异无统计学意义(P>0.05)。结论利用CT引导下的放射性粒子疗法对早期不可手术性NSCLC患者进行治疗的近期疗效及远期生存预后均较好,且安全性也较高,值得在临床上进行推广及应用。Objective To study the clinical effect of CT-guided radioactive particles in treatment of inoperable early-stage non-small cell lung cancer(NSCLC).Methods A total of 49 patients with inoperable NSCLC who were treated from September 2013 to October 2016 were selected in the study.According to the numerical method,25 cases were randomly divided into the observation group and 24 cases in the control group.The control group received chemotherapy regimen of taxol and cisplatin, while the observation group received CT-guided 1251 radioactive particle therapy.After 2 years of follow-up,the short-term efficacy,local tumor control rate,survival rate and adverse reactions were compared.Results The total effective rate of the observation group was 64.00%, which was not statistically significant compared with 58.33% of the control group (P>0.05).The 2 year local control rate and 2 year survival rate of the observation group were significantly higher than the control group,and the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the observation group was 36.00%,compared with 41.67% in the control group,and the difference was not statistically significant (P>0.05). Conclusion CP guided radioactive particle therapy for early inoperable N9CLC patients may gain good short-term efficacy and long-term survival prognosis with high safety, and it is worth of clinical promotion and application.

关 键 词：CT引导 放射性粒子 早期 不可手术性 非小细胞肺癌 临床效果 

分 类 号：R815[医药卫生—放射医学] R734.2[医药卫生—临床医学]