基于维生素D轴探讨黄芪多糖对脓毒症肾上腺皮质功能的保护机制  

Protective Mechanism of Astragalus Polysaccharides on Adrenal Cortex Function in Sepsis Based on VitaminD Axis

作　　者：高洁[1] 蒋志滨 李文[1] 柴艺汇 秦忠[1] 陆婷 胡建军 陈云志[1] GAO Jie;JIANG Zhibin;LI Wen;CHAI Yihui;QIN Zhong;LU Ting;HU Jianjun;CHEN Yunzhi(School of Basic Medical Sciences,Guiyang College of TCM,Guiyang 550002,Guizhou,China;School of pharmacy,Guiyang College of TCM,Guiyang 550002,Guizhou,China;Experiment Center,Guiyang College of TCM,Guiyang 550002,Guizhou,China;Clinical Medicine of Chinese and Western Medicine,Guiyang College of TCM,Guiyang 550002,Guizhou,China)

机构地区：[1]贵阳中医学院基础医学院,贵州贵阳550025 [2]贵阳中医学院药学院,贵州贵阳550025 [3]贵阳中医学院实验中心,贵州贵阳550025 [4]贵阳中医学院中西医临床医学,贵州贵阳550025

出　　处：《中华中医药学刊》2019年第8期1910-1912,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81373517,81760827,81460694,81660762);第四批全国中医(临床、基础)优秀人才研修项目(国中医药人教发[2017]24);贵州省教育厅青年科技人才成长项目(黔科合KY字[2016]187);贵州省教育厅创新群体重大研究项目(黔教合KY字[2017]041);贵州省教育厅项目(黔科合KY[2016]013);贵州省科技计划项目(黔科合基础[2017]1401)

摘　　要：脓毒症(sepsis)是一种具有全身性的炎症反应综合征,常并发于严重创伤、烧伤、感染及大手术等多种应激情况,易诱发脓毒症休克及多器官功能障碍综合征(MODS)。肾上腺皮质功能不全是脓毒症的重要病理改变。另一方面,维生素D不仅与脓毒症密切相关,还对肾上腺皮质功能存在一定调控作用。此外,黄芪多糖可改善脓毒症。基于文献及前期研究表明黄芪具有调节维生素D轴的作用,黄芪多糖具有调节肾上腺皮质的功能,据此提出黄芪多糖可能通过作用于维生素D轴,调节肾上腺皮质功能,从而改善脓毒症。Sepsis is a systemic inflammatory response syndrome, which is associated with severe trauma, burns, infection and major surgery. Sepsis is prone to induce shock and multiple organ dysfunction syndrome(MODS).Adrenocortical insufficiency is an important pathological change in sepsis. Vitamin D is not only closely related to sepsis, but also plays a role in regulating adrenal cortical function. It is reported that astragalus polysaccharides can improve sepsis. Based on literature and previous studies, astragalus has the function of regulating vitamin D axis and adrenal cortex. Therefore, it is proposed that astragalus polysaccharides may regulate adrenal cortex function by acting on vitamin D axis to improve sepsis.

关 键 词：脓毒症 黄芪多糖 HPA轴 肾上腺皮质 

分 类 号：R586[医药卫生—内分泌]