JNK与神经病理性疼痛关系的研究进展  

Advances in Research on Relationship between JNK and Neuropathic Pain

作　　者：文晓娟[1] 张博闻[1] 吴智兵[1,2] WEN Xiaojuan;ZHANG Bowen;WU Zhibing(The First Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《中华中医药学刊》2019年第8期1921-1924,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81373571)

摘　　要：神经病理性疼痛(NP)表现为痛觉过敏、痛觉超敏、炎症区域持续性的自发痛,机制错综复杂,JNK作为MAPKs级联的一员,对NP的影响引起广泛的关注。JNK可通过IL-1R1/TRAF6/JNK通路、GPR14/JNK通路、神经元NMDAR/nNOS/JNK通路、JNK/MMP-2/9/NMDAR通路和JNK/MCP-1通路等导致NP。寻找JNK导致NP活化的底物,对治疗NP有重大意义。中药方剂、针灸、中药单体活性成分也被证实能通过JNK途径缓解NP。Neuropathic pain(NP) is characterized by hyperalgesia, allodynia, spontaneous painand complex mechanisms. JNK, as a member of the MAPKs cascade, has attracted widespread attention. JNK can cause NP through the IL-1 R1/TRAF6/JNK pathway, the GPR14/JNK pathway, the neuronal NMDAR/nNOS/JNK pathway, the JNK/MMP-2/9/NMDAR pathwayand the JNK/MCP-1 pathway. Finding substrates for JNK-induced NP activation is of great significance for the treatment of NP. Traditional Chinese medicine prescriptions, acupuncture and Chinese herbal monomer active ingredients also havebeen shown to relieve NP through the JNK pathway.

关 键 词：神经病理性疼痛(NP) JNK NMDAR 

分 类 号：R441.1[医药卫生—诊断学]