活血散结方结合常规溶栓抗凝治疗急性肺栓塞的效果分析  

Clinical Analysis of Huoxue Sanjie Prescription Combined with Conventional Thrombolysis and Anticoagulation in Treatment of Acute Pulmonary Embolism

作　　者：刘雪莲 刘艳洁 白洁[1] 郭丽娟[1] 扈晓霞[1] 李勇[1] LIU Xuelian;LIU Yanjie;BAI Jie;GUO Lijuan;HU Xiaoxia;LI Yong(Department of Cardiology,Harrison International Peace Hospital,Hengshui 053000,Hebei,China)

机构地区：[1]衡水市哈励逊国际和平医院心血管内科

出　　处：《中华中医药学刊》2019年第8期2021-2024,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省科技计划项目(12276104D-56);衡水市科技计划项目(2017014013C-21)

摘　　要：目的:研究活血散结方结合常规溶栓抗凝治疗急性肺栓塞的临床效果分析。方法:选择急性肺栓塞患者96例,根据Excel随机表格法分为对照组和观察组,对照组48例、观察组48例;对照组患者采用常规溶栓抗凝方法治疗,观察组在对照组治疗的基础上,加用活血散结方治疗。两组连续治疗3个月后观察治疗疗效。对比两组患者治疗疗效、对比两组患者治疗前后动脉血气PaO2、PaCO2变化、对比两组患者治疗前后D-二聚体、血氧分压、二氧化碳分压水平变化、对比两组患者治疗前后中医证候积分。结果:研究结果显示,观察组总有效率达到93.75%,对照组总有效率达到77.08%,观察组总有效率显著优于对照组(P<0.05)。观察组治疗后PaO2水平对比高于对照组,且PaCO2低于对照组(P<0.05)。观察组治疗后D-二聚体水平对比低于对照组,且血氧分压、二氧化碳分压水平水平高于对照组(P<0.05)。观察组治疗后呼吸困难、胸痛积分优于对照组(P<0.05)。结论:综上所述总结得出,活血散结方结合常规溶栓抗凝药物治疗急性肺栓塞患者疗效显著,降低了D-二聚体水平,改善了急性肺栓塞患者临床症状,提高了治疗疗效,充分体现了中医异病同治的辨证施治方法,值得临床推广运用。Objective:To study the clinical effect of Huoxue Sanjie Prescription combined with conventional thrombolysis and anticoagulation on acute pulmonary embolism.Methods:Ninety-six patients with acute pulmonary embolism admitted to the respiratory and cardiology department of our hospital from April 2015 to March 2018 were divided into control group and observation group according to Excel random table method, 48 cases in control group and 48 cases in observation group.The patients in control group were treated with routine acid-dissolving anticoagulant therapyand those in observation group were treated with Huoxue SanjiePrescription on the basis of control group. After 3 months treatment,we compared the curative effect of two groups, the changes of PaO2 and PaCO2 of arterial blood gas before and after treatment, the changes of D-dimer, oxygen partial pressure and carbon dioxide partial pressure before and after treatment, the scores of TCM syndromes before and after treatment of two groups.Results:The total effective rate of the observation group was 93.75%, and that of the control group was 77.08%. The total effective rate of the observation group was significantly better than that of the control group(P<0.05). After treatment, the results showed that the PaO2 level in the observation group was higher than that in the control group, and the PaCO2 level was lower than that in the control group. The difference was statistically significant(P<0.05). After treatment, the results showed that the level of D-dimer in the observation group was lower than that in the control group, and the levels of oxygen partial pressure and carbon dioxide partial pressure were higher than those in the control group(P<0.05). After treatment, the results showed that the breathing difficulties and chest pain scores of the observation group were better than those of the control group and the difference was statistically significant(P<0.05). Conclusion:To sum up, Huoxue Sanjie Prescription combined with conventional thrombolytic and anticoagul

关 键 词：活血散结方 溶栓抗凝 急性肺栓塞 

分 类 号：R563.5[医药卫生—呼吸系统]