中药联合华法林治疗急性次大面积肺栓塞的临床疗效  

Clinical Efficacy of Chinese Medicine Combined with Warfarin in Treatment of Acute Massive Pulmonary Embolism

作　　者：胡梦玮 张思泉 HU Mengwei;ZHANG Siquan(Respiratory Department,Jiaxing Second People’s Hospital,Jiaxing 314000,Zhejiang,China;Respiratory Department,Hangzhou Xixi Hospital,Hangzhou 310012,Zhejiang,China)

机构地区：[1]嘉兴市第二医院呼吸内科,浙江嘉兴314000 [2]杭州市西溪医院呼吸内科,浙江杭州310012

出　　处：《中华中医药学刊》2019年第8期2029-2032,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省医药卫生一般研究计划项目(2013KYA170)

摘　　要：目的:研究中药汤剂联合华法林治疗急性次大面积肺栓塞的临床疗效。方法:选择72例急性次大面积肺栓塞的患者,全部病例符合2001年中华医学会呼吸病学分会制定的《肺血栓栓塞症的诊断与治疗指南(草案)》的诊断标准,经CT肺动脉造影(CTPA)和心脏超声心动图明确诊断的次大面积肺栓塞患者72例,并分为治疗组和对照组各36例,实验组患者采用中药汤剂联合华法林及肝素治疗,对照组患者采用低分子肝素和华法林抗凝治疗,比较两组患者治疗效果。对患者的危险因素、症状、体征及辅助检查资料进行分析。结果:实验组患者临床疗效明显高于对照组,动脉血气分析指标变化情况、脑钠肽(BNP)水平改善情况均优于对照组,两组比较差异具有统计学意义(P<0.05)。结论:中药联合肝素钠及华法林溶栓治疗急性次大面积肺栓塞是一种安全有效的方法。Objective:To study the clinical efficacy of traditional Chinese medicine decoction combined with warfarin in the treatment of acute sublarge pulmonary embolism.Methods:72 patients with acute massive pulmonary embolism in our hospital were selected. All the patients met the diagnostic criteria of Guidelines for the Diagnosis and Treatment of Pulmonary Thromboembolism(Draft) issued by Respiratory Society of Chinese Medical Association in 2001. The results were confirmed by CT pulmonary angiography(CTPA) and echocardiography. Eighty patients with secondary massive pulmonary embolism were divided into treatment group(n=36) and control group(n=36). The experimental group was treated with traditional Chinese medicine decoction combined with warfarin and heparin, while the control group was treated with low molecular weight heparin and warfarin anticoagulant therapy. The therapeutic effects of the two groups were compared. The risk factors, symptoms, signs and auxiliary examination data were analyzed.Results:The clinical efficacy of the experimental group was significantly higher than that of the control group and the changes of arterial blood gas analysis index and the improvement of brain natriuretic peptide(BNP) level were better than those of the control group. The difference between the two groups was statistically significant(P<0.05). Conclusion:Chinese medicine combined with heparin sodium and warfarin thrombolysis is a safe and effective method for the treatment of acute sublarge pulmonary embolism.

关 键 词：中药 肺栓塞 法华林 

分 类 号：R563.5[医药卫生—呼吸系统]