草酸艾司西酞普兰联合rTMS治疗脑梗死后抑郁的疗效及对神经功能的影响  

Efficacy of oxalic acid escitalopram combined with rTMS in the treatment of depression after cerebral infarction and its effect on nerve function

作　　者：杨华 聂艳[1] 宁若辰 YANG Hua;NIE Yan;NING Ruo-chen(Jingzhou Mental Health Center, Hubei Jingzhou 434000, China)

机构地区：[1]荆州市精神卫生中心

出　　处：《中国医院药学杂志》2019年第15期1578-1581,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探寻草酸艾西酞普兰联合重复经颅磁刺激(rTMS)治疗脑梗死后抑郁的临床疗效,并观察其对神经功能的影响。方法:选取某院2015年5月-2017年5月收治的100例脑梗死后抑郁患者为研究对象,将其按随机数字表法分为观察组和对照组,对照组行草酸艾西酞普兰治疗,观察组行草酸艾西酞普兰联合rTMS治疗,观察2组患者的抑郁缓解情况、神经功能恢复情况、HAMD评分、BI评分、不同时间段的NIHSS评分变化情况。结果:观察组抑郁缓解总有效率76%显著高于对照组总有效率60%(χ^2=3.945,P<0.05),观察组神经功能恢复总有效率78%显著高于对照组总有效率68%(χ^2=5.195,P<0.05)。治疗后,观察组患者的HAMD评分[(14.85±1.95)分]显著低于对照组[(18.27±2.57)分],BI评分[(86.22±6.51)分]显著高于对照组[(65.37±7.21)分],差异具有显著性(P均<0.05)。治疗前2组NIHSS评分无差异(P>0.05),治疗后7 d观察组NIHSS评分[(11.38±3.17)分]显著低于对照组[(13.34±3.31)分],治疗后28 d观察组NIHSS评分[(5.29±2.56)分]显著低于对照组[(8.06±3.25)分],差异具有显著性(P均<0.05)。结论:草酸艾西酞普兰联合rTMS治疗脑梗死后抑郁患者具有较好临床疗效,可进一步缓解患者的抑郁症状,促进其神经功能恢复。OBJECTIVE To explore the clinical efficacy of oxalic acid escitalopram combined with repeated transcranial magnetic stimulation(rTMS) in the treatment of depression after cerebral infarction. METHODS A total of 100 patients with depression after cerebral infarction admitted from May 2015 to May 2017 in a hospital were selected as study subjects. The patients were divided into observation group and control group according to random number table method. The patients in the control group were treated with oxalic acid escitalopram. The patients in the observation group were treated with oxalic acid escitalopram combined with rTMS. The depression relief, neural function recovery, Hamd score and BI score were compared between the two groups. The changes of NIHSS score at different time points were also observed. RESULTS The total effective rate of depression remission 76% in the observation group was significantly higher than that 60% in the control group(χ~2=3.945, P<0.05), and the total effective rate of nerve function recovery 78% in the observation group was significantly higher than that 68% in the control group(χ~2=5.195, P<0.05). After treatment, the HAMD score(14.85±1.95) of the observation group was significantly lower than that of the control group(18.27±2.57), and the BI score(86.22±6.51) was significantly higher than that of the control group(65.37±7.21), and the differences had statistical significance(P<0.05). There was no difference in NIHSS scores between the two groups before treatment(P>0.05). The NIHSS score [(11.38±3.17) points] in the control group was significantly lower than that in the control group [(13.34±3.31) points]. The NIHSS score at 28 d after treatment in the observation group [(5.29±2.56) points] was significantly lower than that in the control group [(8.06±3.25) points], and the difference was statistically significant(P<0.05). CONCLUSION Oxalic acid escitalopram combined with rTMS has good clinical efficacy in the treatment of depression after cerebral infarction, which can

关 键 词：草酸艾司西酞普兰 重复经颅磁刺激 脑梗死后抑郁 神经功能 

分 类 号：R969[医药卫生—药理学]