中医药调节肿瘤免疫微环境研究进展  

Research Progress of Chinese Medicine in Regulating Tumor Immune Micro-environment

作　　者：杨娜[1] 吴琳 刘晓彤 闫敏 李星[1] 叶峥嵘[1] YANG Na;WU Lin;LIU Xiaotong;YAN Min;LI Xing;YE Zhengrong(Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China;Xianyang Central Hospital,Xianyang 712000,Shaanxi,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]咸阳市中心医院,陕西咸阳712000

出　　处：《辽宁中医药大学学报》2019年第8期164-167,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：陕西省教育厅科学研究项目(17JK0204);陕西省中医管理局中医药科研课题项目(JCMS073);咸阳市科学技术研究计划项目(2017k02-93)

摘　　要：肿瘤的发生发展与肿瘤免疫微环境密切相关。在肿瘤的形成过程中,肿瘤免疫微环境不仅能够促进肿瘤的发生发展,也能够抑制肿瘤的发生发展。中医药对肿瘤免疫微环境中的细胞毒性T细胞、自然杀伤细胞、树突状细胞、IL-12有正向调节作用,对肿瘤免疫微环境中的调节性T细胞、肿瘤相关巨噬细胞、髓系来源的抑制性细胞、PD-1/PD-L1有负向调节作用。应重视中医药调节肿瘤免疫微环境的作用机制研究。The occurrence and development of tumors are closely related to the tumor immune microenvironment.In the process of tumor formation,the tumor immune micro-environment can not only promote the occurrence and development of tumors,but also inhibit the occurrence and development of tumors.Traditional Chinese medicine has a positive regulatory effect on cytotoxic T cells,nature killer cells,dendritic cells,and IL-12 in the tumor immune micro-environment.Regulatory T cells and tumorassociated macrophages in the tumor immune micro-environment,myeloid-derived suppressor cells,PD-1/PD-L1,have a negative regulatory effect.Attention should be paid to the research on the mechanism of action of TCM to regulate the tumor immune micro-environment.

关 键 词：中医药 肿瘤免疫微环境 正向调节 负向调节 研究进展 

分 类 号：R273[医药卫生—中西医结合]