行气活血汤对腹腔镜胆囊切除术后血清炎症因子、胃肠功能及并发症影响  

Effect of Xingqi Huoxue Decoction on Serum Inflammatory Factors Gastrointestinal Function and Complications after Laparoscopic Cholecystectomy

作　　者：刘斌[1] 蒋谦[2] 许竹青[1] 柏磊[1] 刘坤[3] LIU Bin;JIANG Jian;XU Zhuqing;BAI Lei;LIU Kun(Suqian Hospital Affiliated to Nanjing University of Traditional Chinese Medicine,Suqian 223800,Jiangsu,China;Jiangsu Cancer Hospital,Nanjing 210009,Jiangsu,China;Suqian People's Hospital,Nanjing Drum-Tower Hospital Group,Suqian 223800,Jiangsu,China)

机构地区：[1]南京中医药大学附属宿迁市中医院,江苏宿迁223800 [2]江苏省肿瘤医院,江苏南京210000 [3]南京鼓楼集团宿迁市人民医院,江苏宿迁223800

出　　处：《辽宁中医药大学学报》2019年第8期181-184,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：宿迁市科学技术局指导性科技计划项目(Z201506)

摘　　要：目的:探讨行气活血汤对腹腔镜胆囊切除术(LC)术后患者血清炎症因子、肠胃功能及并发症的影响。方法:选取2017年5月—2018年7月于我院择期行LC治疗的112例患者,利用随机数字表法将这112例患者随机分成观察组(n=56)与对照组(n=56)。两组术后均常规给予相同的补液及抗感染等支持治疗,观察组在此基础上联合行气活血汤内服。比较两组术后胃肠功能恢复情况,手术前后检测两组炎症因子[白介素(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)]及胃肠激素[胃泌素(GAS)、胃动素(MTL)、血管活性肠肽(VIP)]血清水平,并统计两组术后并发症发生情况。结果:观察组术后进食、肠鸣音恢复、肛门排气及排便时间均明显短于对照组(P<0.05)。观察组术后1、3d时血清GAS、MTL浓度较对照组同期均显著更高(P<0.05),而VIP水平则均显著更低(P<0.05);且观察组术后1、3d时各项炎性因子(IL-6、TNF-α、CRP)血清含量均显著低于对照组同期(P<0.05)。观察组无恶心腹胀发生,其恶心腹胀发生率显著低于对照组(7.14%,P<0.05)。结论:LC术后应用行气活血汤辅助治疗能有效缓解患者机体炎症反应,促进胃肠功能的恢复,且尚可减少并发症发生。Objective:To explore effect of Xingqi Huoxue Decoction on serum inflammatory factors,gastrointestinal function and complications after laparoscopic cholecystectomy(LC).Methods:Selected 112 cases who underwent elective LC treatment in our hospital from May 2017 to July 2018,and divided them into observation group(n=56)and control group(n=56)randomly.Provided same rehydration and anti-infective supportive treatment to both group routinely,provided oral Xingqi Huoxue Decoction to observation group additionally.Compared two groups'postoperative gastrointestinal function recovery,inflammatory factors[interleukin(IL-6),tumor necrosis factor(TNF-α),C-reactive protein(CRP)],gastrointestinal hormones[gastrin(GAS),motilin(MTL),vasoactive intestinal peptide(VIP)]levels in serum before and after operation,as well as statistics of postoperative complications in both groups.Results:Observation group's postoperative feeding,bowel sound recovery,anal exhaust and defecation time were significant shorter than those in control group(P<0.05).Observation group's serum GAS,MTL concentration at postoperative 1,3 d were significant higher than those in control group(P<0.05),and VIP level was significant lower(P<0.05),and observation group's serum levels of inflammatory factors(IL-6,TNF-α,CRP)at 1,3 d were significant lower than those in control group at same time(P<0.05).There was no nausea and abdominal distension in observation group,and the incidence of nausea and abdominal distension was significant lower than that in control group(7.14%,P<0.05).Conclusion:The application of Xingqi Huoxue Decoction helps patients after LC operation to alleviate the inflammatory response and promote the recovery of gastrointestinal function effectively,as well as reduce complications.

关 键 词：行气活血汤 腹腔镜胆囊切除术 炎症因子 胃肠功能 并发症 

分 类 号：R285.5[医药卫生—中药学]