系统性红斑狼疮病人外周血血清TGF-β1的表达及临床意义  

Expression of TGF-β1 in peripheral blood from patients with systemic lupus erythematosus and its clinical significance

作　　者：王涛[1] 江超[1] 赵萍[1] 叶明[1] 陈琳洁[1] WANG Tao;JIANG Chao;ZHAO Ping;YE Ming;CHEN Lin-jie(Department of Rheumatology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科

出　　处：《蚌埠医学院学报》2019年第7期868-871,875,共5页Journal of Bengbu Medical College

基　　金：国家高新技术研究发展计划(863计划)课题(012AA02A513);安徽省高等学校自然科学研究一般项目(KJ2015B017by);安徽省教育厅高校优秀青年人才国外访问研修项目(gxgwfx2018053)

摘　　要：目的:通过检测转化生长因子β1(TGF-β1)在系统性红斑狼疮(SLE)病人外周血的表达,分析其与临床资料的相关性。方法:选择56例SLE病人(观察组)和35名健康志愿者(对照组),根据是否合并狼疮肾炎(LN),将56例SLE病人分为合并LN组和无LN组,收集SLE病情活动指数(SLEDAI)等临床资料及实验室检查。采用ELISA方法检测血清TGF-β1,并将检测指标与临床资料及实验室检查指标作相关性分析。结果:SLE合并LN病人TGF-β1水平低于对照组(P<0.05)。低活动组SLE病人TGF-β1水平低于高活动组SLE病人(P<0.05)。观察组病人外周血血清在关节炎受累的病人组中表达较高(P<0.05),抗U1RNP抗体、抗Sm-D1抗体阳性的病人组中表达较低(P<0.05);TGF-β1的水平与SLEDAI、C3、红细胞沉降率、C反应蛋白无相关性(P>0.05),与外周血RBC计数呈正相关(P<0.05),与24h尿蛋白定量、血清IgM、球蛋白和天门冬氨酸氨基转移酶的水平呈负相关(P<0.05)。结论:TGF-β1具有双向免疫调节的作用,可能参与SLE的肾脏及关节病理。Objective: To examine the status and clinical significance of serum transforming growth factor (TGF)-β1 in peripheral blood from patients with systemic lupus erythematosus (SLE). Methods: A total of 56 SLE patients and 35 healthy individuals were recruited into this study.According to the presence of lupus nephritis (LN),the SLE patients were divided into two groups:those with LN and those without LN.The serum levels of TGF-β1 were measured using ELISA.The associations between these measurements and SLE disease activity index (SLEDAI) or other laboratory parameters were analyzed by correlation analysis. Results: The serum TGF-β1 level in the SLE patients with LN was significantly lower than that in the healthy controls ( P <0.05).The serum TGF-β1 level in the SLE patients with lower disease activity was significantly lower than that in patients with higher disease activity( P <0.05).The serum TGF-β1 level was higher in the patients with arthritis than those without,and was lower in the patients with positive anti-U1RNP or anti-Sm-D1 antibody than those of negative.Correlation analysis showed that the serum TGF-β1 level was not significantly correlated with the SLEDAI score,C3 level,erythrocyte sedimentation rate and C reactive protein( P >0.05),but it was positively correlated with the red blood cell count and negatively correlated with globulin,24 h urine protein,serum IgM and AST( P <0.05). Conclusions: TGF-β1 has a two-way immunomodulatory effect and may be involved in the pathology of kidney and joint in SLE patients.

关 键 词：系统性红斑狼疮 转化生长因子Β1 狼疮肾炎 

分 类 号：R593.24[医药卫生—内科学]