血细胞分析参数与子痫前期的相关性分析  

Correlation analysis between blood cell parameters and preeclampsia

作　　者：王璐 李睿 黄新明[1] 张松涛 WANG Lu;LI Rui;HUANG Xin-ming;ZHANG Song-tao(Department of Clinical Laboratory,Lu′an People′s Hospital,Lu′an Anhui 237000,China;Department of Obstetrics,Lu′an People′s Hospital,Lu′an Anhui 237000,China)

机构地区：[1]安徽省六安市人民医院检验科,237000 [2]安徽省六安市人民医院产科,237000

出　　处：《蚌埠医学院学报》2019年第7期943-945,共3页Journal of Bengbu Medical College

摘　　要：目的:分析探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、红细胞分布宽度变异系数(RDW-CV)、平均血小板体积(MPV)在正常妊娠与子痫前期间的相关性,及MPV在子痫前期中的诊断价值。方法:选取轻度子痫前期34例、重度子痫前期57例及同期正常妊娠孕妇54名(对照组),空腹抽取静脉血,进行全血细胞分析,比较NLR、PLR、RDW-CV、血小板分布宽度(PDW)、MPV。结果:对照组与轻度子痫前期组及重度子痫前期组的MPV水平差异均具有统计学意义(P<0.05)。对照组年龄、中性粒细胞计数(N)、淋巴细胞计数、PDW、MPV水平与子痫前期组相比差异具有统计学意义(P<0.05~P<0.01)。轻度子痫前期组与重度子痫前期之间N差异具有统计学意义(P<0.05),MPV水平无差异。MPV=10.35时诊断子痫前期的敏感度为68.5%,特异度为87.0%。结论:MPV与子痫前期的发生密切相关,是诊断子痫前期的有效标志物。Objective: To investigate the correlation of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),coefficient of variation of erythrocyte distribution width(RDW-CV) and mean platelet volume(MPV) between normal pregnancy and preeclampsia,and diagnostic value of MPV in preeclampsia. Methods: The whole blood cell in 34 pregnant women with mild preeclampsia,57 pregnant women with severe preeclampsia and 54 normal pregnant women(control group) were analyzed.The NLR,PLR,RDW-CV,distribution width of platelet(PDW) and MPV among all patients were analyzed. Results: The differences of the levels of MPV among control group,mild preeclampsia group and severe preeclampsia group were statistically significant( P <0.05).The differences of the age,neutrophil count,lymphocyte count,PDW and MPV between the control group and preeclampsia group were statistically significant( P <0.05 to P <0.01).The difference of neutrophil count between mild preeclampsia group and severe preeclampsia group was statistically significant( P <0.05).The sensitivity and specificity of MPV=10.35 was 68.5% and 87.0%,respectively. Conclusions: MPV is closely correlated with to the occurrence of preeclampsia,and an effective marker for diagnosis of preeclampsia.

关 键 词：子痫前期 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 红细胞分布宽度变异系数 血小板分布宽度 平均血小板体积 

分 类 号：R714.244[医药卫生—妇产科学]