穴位刺激调控法联合艾司西酞普兰治疗惊恐障碍39例  

Effect of Transcutaneous Electrical Acupoint Stimulation Combine with Escitalopram in the Treatment of 39 Patients with Panic Disorder

作　　者：刘兰英[1] 骆利元 朱春青[1] 蒋璐 冯斌[1] LIU Lanyin;LUO Liyuan;ZHU Chunqing;JIANG Lu;FENG Bin(Department of Psychiatry,Tongde Hospital of Zhejiang Province,Mental Health Center of Zhejiang Province,Hangzhou 310012,China)

机构地区：[1]浙江省立同德医院浙江省精神卫生中心精神科

出　　处：《医药导报》2019年第9期1187-1191,共5页Herald of Medicine

基　　金：浙江省首届医坛新秀项目资助(2013245)

摘　　要：目的探讨穴位刺激调控法联合艾司西酞普兰治疗惊恐障碍疗效。方法将符合诊断标准的惊恐障碍患者机分为治疗组(39例)和对照组(40例),对照组给予艾司西酞普兰口服,每天1次,第1周10mg·d^-1,第2周至第8周20mg·d^-1;治疗组在对照组基础上加用穴位刺激调控法治疗,连续观察8周,比较两组的疗效与安全性。结果两组治疗前后汉密尔顿焦虑量表(HAHA)评分、惊恐障碍严重度量表(PDSS)评分比较,均差异有统计学意义(均P<0.01),均取得明显疗效。组间比较,在第2,4,8周末两组HAMA评分差异有统计学意义,躯体性焦虑因子评分比较,两组在第2,4周末躯体评分差异有统计学意义(P<0.05)。精神性焦虑因子评分比较,两组第2,4,8周末差异有统计学意义(P<0.05)。减分率比较:两组在第2,4,8周末HAMA评分减分率、焦虑评分减分率均差异有统计学意义(P<0.05),而躯体评分减分率在第2,4周差异有统计学意义(P<0.05)。两组间PDSS评分在第2,4,8周末均差异有统计学意义(P<0.01)。两组SERS量表评分比较,两组差异无统计学意义,主要不良反应为食欲下降、出汗、恶心、失眠、口干、头晕等。结论穴位刺激调控法能提高艾司西酞普兰的疗效,并明显改善治疗早期的躯体症状,快速起效。Objective To explore the effect of transcutaneous electrical acupoint stimulation combine with escitalopram in patients with panic disorder.Methods According to the principle of randomization,patients were divided in research group(39 cases)and control group(40 cases).The control group was treated with escitalopram for 8 weeks(10 mg·d^-1 for first week and 20 mg·d^-1 from week 2 to week 8).And the research group was treated with transcutaneous electrical acupoint stimulation combine with escitalopram for 8 weeks.The safety and efficacy were evaluated in both groups at week 2,4 and 8.Results The scores of Hamilton anxiety scale(HAMA),panic disorder severity scale(PDSS)were significantly different between research group and control group at week 2,4 and 8(P<0.01).Somatization factors rating scores were significantly different between research group and control group at week 2 and 4(P<0.05).Anxiety factors rating scores were significantly different between research group and control group at week 2,4 and 8(P<0.05).The reducing rates of HAMA score and anxiety factors score were significantly different between research group and control group at week 2,4 and 8(P<0.05).The reducing rates of somatization factors score-were statistically different between research group and control group at week 2 and 4(P<0.05).The scores of PDSS were statistically significant difference between the research group and the control group at week 2,4,8(P<0.01).There was no significant difference between the research group and the control group in the score of SERS.The major side effects were loss of appetite,sweatiness,nausea,insomnia,dry mouth,and dizziness.Conclusion Transcutaneous electrical acupoint stimulation could improve the efficacy of escitalopram in patients with panic disorder,and significantly relieve the somatization at the beginning of treatment.

关 键 词：艾司西酞普兰 穴位刺激调控法 惊恐障碍 

分 类 号：R971.4[医药卫生—药品] R245.9[医药卫生—药学]