黄芪注射液对造影剂相关性肾病中性粒细胞明胶酶相关载脂蛋白水平的影响  

Effect of Astragalus injection on neutrophil gelatinase associated lipocalin level in patients with contrast-induced nephropathy

作　　者：肖永佳 柳梅[3] 彭大艳 XIAO Yong-jia;LIU Mei;PENG Da-yan(Nephrology Department, Jingzhou Hospital of Traditional Chinese Medicine, Jingzhou 434000, China)

机构地区：[1]湖北荆州市中医医院肾病科,荆州434000 [2]湖北荆州市中医医院心病科,荆州434000 [3]武汉市第一医院重症监护室,武汉430022

出　　处：《临床肾脏病杂志》2019年第8期590-593,共4页Journal Of Clinical Nephrology

基　　金：湖北省自然科学基金项目(2018CFB353);武汉市中青年医学骨干人才(2018[116])

摘　　要：目的研究黄芪注射液对造影剂相关性肾病中性粒细胞明胶酶相关载脂蛋白(NGAL)水平的影响。方法纳入2015年6月至2017年6月在静脉使用造影剂并诊断为造影剂相关性肾病的患者64例,随机分为治疗组和对照组,治疗组给予黄芪注射液20~30mL,加入生理盐水250mL静脉滴注,1次/天。对照组给予等量的生理盐水。比较两组患者治疗前以及治疗后24h,48h,72h的血Scr和尿NGAL。结果治疗组在诊断造影剂相关性肾病后24h、48h、72h的血Scr水平和尿NGAL水平均明显低于对照组。结论黄芪注射液能显著降低造影剂相关性肾病诊断后24h、48h、72h的血Scr水平和尿NGAL水平,对肾脏具有一定的保护功能。Objective To investigate effect of Astragalus injection on neutrophil gelatinase associated lipocalin(NGAL) level in patients with contrast- induced nephropathy. Methods A total of 64 patients using contrast in the vein and diagnosed with contrast-induced nephropathy from June 2015 to June 2017 were included, and divided into Astragalus group and control group randomly. The patients in the Astragalus group were administered with 20~30 mL Astragalus injection +250 mL physiological saline in a route of intravenous drip, once per day. The patients in the control group were administered with the same amount of physiological saline. Scr and urinary NGAL between the two groups were compared at 24 h, 48 h and 72 h before and after treatment. Results Scr and urinary NGAL levels in the Astragalus group at 24 h, 48 h and 72 h after diagnosis of contrast-induced nephropathy were significantly lower than those in the control group. Conclusions Astragalus injection can significantly reduce Scr and urinary NGAL levels at 24 h, 48 h and 72 h after diagnosis of contrast-induced nephropathy, and protect the kidney.

关 键 词：黄芪 造影剂相关性肾病 中性粒细胞明胶酶相关载脂蛋白 

分 类 号：R692[医药卫生—泌尿科学]