盐酸川芎嗪对NPDR患者视力血管内皮功能的影响  

Effects of Tetramethylpyrazine Hydrochloride on Visual Acuity and Vascular Endothelial Function in NPDR Patients

作　　者：王乾 刘岩 林慧 李咏 毕占京[3] WANG Qian(PLA Army 82 Group Military Hospital, Hebei Baoding 071000, China)

机构地区：[1]解放军陆军八十二集团军医院眼科,河北保定071000 [2]华北理工大学附属医院眼科,河北唐山063000 [3]河北省保定市第一中心医院眼一科,河北保定071000

出　　处：《河北医学》2019年第8期1273-1276,共4页Hebei Medicine

基　　金：河北省2017年度医学科学研究重点课题,(编号:20170198);河北省教育厅河北省高等学校科学技术研究项目,(编号:QN2018215)

摘　　要：目的:非增值期糖尿病视网膜病变(NPDR)患者采用盐酸川芎嗪治疗对视力、血管内皮功能的影响.方法:选取我院2016年10月至2018年10月间收治的142例NP DR患者,采用简单随机分组法分为两组.两组患者均给予基础治疗,对照组71例给予患者羟苯磺酸钙片治疗,观察组71例患者在对照组基础上给予盐酸川芎嗪片治疗.比较两组治疗疗效,治疗前后视力、眼压,黄斑水肿和黄斑厚度,及血浆血管内皮生长因子(VEGF)、内皮素-1(ET-1)水平和血管内皮依赖性舒张功能(FMD)变化.结果:观察组治疗总有效率92.96%,明显高于对照组的81.69%(P<0.05);治疗后,观察组视力显著优于对照组(P<0.05),黄斑水肿评分显著低于对照组,黄斑厚度显著小于对照组(P<0.05);观察组VEGF、ET-1水平显著低于对照组,FMD值显著高于对照组(P<0.05);但两组治疗前后眼压均无明显变化(P>0.05).结论:盐酸川芎嗪可有效改善NPDR患者视力,减轻黄斑水肿,提高患者血管内皮功能.Objective: To explore the effects of tetramethylpyrazine hydrochloride on visual acuity and vascular endothelial function in patients with non-prolifertive diabetic retinopathy (NPDR). Methods: A total of 142 patients with NPDR admitted to our hospital from October 2016 to October 2018 were selected and divided into two groups according to the simple random grouping. The two groups were given basic treatment, and 71 patients in control group were treated with calcium dobesilate tablets, and 71 patients in observation group were given tetramethylpyrazine hydrochloride tablets on the basis of control group. The treatment efficacy, and visual acuity, intraocular pressure, macular edema and macular thickness, and plasma vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and endothelium-dependent flow-mediated dilatation (FMD) before and after treatment were compared between the two groups. Results: The total effective rate of treatment in observation group was significantly higher than that in control group (92.96% vs 81.69%)(P<0.05). After treatment, the visual acuity in observation group was significantly better than that in control group (P<0.05), and the macular edema score was significantly lower than that in control group, and the macular thickness was significantly lower than that in control group (P<0.05). The levels of VEGF and ET-1 in observation group were significantly lower than those in control group while the FMD value was significantly higher than that in control group (P<0.05). However, there was no significant change in intraocular pressure between the two groups before and after treatment (P>0.05). Conclusion: Teramethylpyrazine hydrochloride can effectively improve the vision of NPDR patients, reduce macular edema and improve vascular endothelial function.

关 键 词：NPDR 盐酸川芎嗪 视力 血管内皮功能 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]