基于功能化的纳米锐钛矿TiO2膜修饰电极的乌药醚内酯电化学传感器及其应用研究  

CONSTRUCTION AND APPLICATION OF LINDERANE ELECTROCHEMICAL SENSOR BASED ON FUNCTIONALIZED NANO-TIO2 MODIFIED ELECTRODE

作　　者：余丽双[1] 孙照霞[1] 陈莉[1] 林晓[1] 赖昕[1] YU Li-shuang;SUN Zhao-xia;CHEN Li;LIN Xiao;LAI Xin(College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China)

机构地区：[1]福建中医药大学药学院

出　　处：《井冈山大学学报（自然科学版）》2019年第4期18-22,共5页Journal of Jinggangshan University (Natural Science)

基　　金：福建省科技厅计划项目(2017Y0051,2018J01871);福建省教育厅计划项目(JZ160445,JAT170288);福建省卫计委项目计划(2017-2-48);福建中医药大学校管课题重点专项(X2017012-重点)

摘　　要：将功能化的纳米锐钛矿TiO2(介笼结构)修饰电极作为乌药醚内酯电化学传感器的氧化还原探针,实现电化学方法检测乌药醚内酯。实验优化了电极修饰液用量、支持电解质和仪器参数等条件。在最优化的条件下,乌药醚内酯的线性范围为0.1~20μg/mL,检测限为0.058μg/m L。将所建立的电化学新方法应用于乌药中乌药醚内酯类的含量测定及药材真伪的鉴定,测得其平均含量为0.303 mg/g,并实现乌药与其伪品荆三棱药材的快速鉴别。The functionalized nanoparticulate anatase TiO2(mesoporous structure)modified electrode was used as the redox probe of the electrochemical sensor of linderane,which could be applied to detect linderane.The experiment optimized the experimental conditions,such as the amount of electrode modification solution,supporting electrolyte and instrument parameters.Under the optimal conditions,the linear range of linderane ranged from 0.1μg/mL to 20μg/mL with a detection limit of 0.058μg/mL.The new electrochemical method was applied to determine the content of linderane in Scirpus maritimus,and identify it and its counterfeit S.yagara.

关 键 词：乌药醚内酯 电化学传感器 功能化纳米锐钛矿TiO2 修饰电极 

分 类 号：R917[医药卫生—药物分析学]