2013～2017年医院尿路感染住院患者抗菌药物应用分析  

ANALYSIS OF ANTIMICROBIAL AGENTS APPLICATION IN PATIENTS WITH URINARY TRACT INFECTION IN HOSPITAL FROM 2013 TO 2017

作　　者：常国伟 周航 胡文 陈春林[1] CHANG Guo-Wei;ZHOU Hang;HU Wen;CHEN Chun-lin(College of Chemical and Biological Engineering,Yichun University,Yichun,Jiangxi 336000,China;Department of Pharmacy,Yichun Municipal People's Hospital,Yichun,Jiangxi 336000,China)

机构地区：[1]宜春学院化学与生物工程学院,江西宜春336000 [2]宜春市人民医院药剂科,江西宜春336000

出　　处：《井冈山大学学报（自然科学版）》2019年第4期103-106,共4页Journal of Jinggangshan University (Natural Science)

摘　　要：目的通过调查医院2013~2017年尿路感染住院患者抗菌药物使用情况,为评价临床药师参与临床用药中发挥的作用提供依据。方法检索宜春市人民医院2013~2017年456例尿路感染住院患者病例资料,分析比较2013~2015与2016~2017年抗菌药物的使用与患者治疗情况。包括用药频度(DDDs)、平均使用品种、联合用药率、换药率、选药不合理率、剂量不合理率、疗程不合理率、平均住院天数及治愈率。结果2013~2015年氟喹诺酮类药物DDDS排序均为第一;2016~2017年头孢菌素类药物DDDS排序均为第一;单类品种中,左氧氟沙星DDDs排序在2013~2016年期间为第一;2017年时氨曲南DDDS排序位居首位而左氧氟沙星位居第五;2013~2017年患者平均用药品种数与疗程不合理率无显著变化,联合用药率、换药率于2016~2017年较以往有明显降低P<0.01,P<0.05,但平均住院天数较往年有明显升高P<0.05。剂量不合理率、选药不合理率较往年降低而治愈率较往年有所提高。结论在临床药师的参与下,尿路感染患者抗菌药物用药逐渐走向更加规范合理,尿路感染患者的抗菌药物应用得到有效控制。Objective:To investigate the use of antibiotics in hospitalized patients with urinary tract infections from 2013 to 2017,and to provide evidence for evaluating the role of clinical pharmacists in clinical drug use.Methods:The data of 456 hospitalized patients with urinary tract infection in Yichun People’s Hospital from 2013 to 2017 were retrieved,the use of antibiotics and patient treatment in 2013-2015 and 2016-2017 were analyzed and compared.It included the frequency of medication(DDDs),the average use of the variety,the combination of drug rates,dressing rate,unreasonable drug selection rate,unreasonable dose rate,unreasonable treatment rate,average days of hospital stay and cure rate.Results:The orders of fluoroquinolone DDDS and cephalosporin DDDS were the first in 2013-2015 and 2016-2017 respectively;in the single-species,levofloxacin DDDs ranked first in 2013-2016;aztreonam DDDS ranked first and levofloxacin ranked fifth in 2017.There were no significant changes in the average number of patients and the unreasonable rate of treatment in 2013-2017.The combined drug use rate and dressing rate were significantly lower in 2016-2017 than those in the past(P<0.01,P<0.05),but the average hospitalization days were significantly higher than those in previous years(P<0.05).In 2017,The unreasonable dose rate and the unreasonable rate of patient selection were lower than those in previous years,and the cure rate was improved compared with previous years.Conclusion:Basing on the participation of clinical pharmacists,the use of antibiotics in patients with urinary tract infections has gradually become more standardized and rational,and the application of antibacterial drugs in patients with urinary tract infections has been effectively controlled.

关 键 词：抗菌药物 尿路感染 合理用药 药师服务 

分 类 号：R691.3[医药卫生—泌尿科学]