早泄患者右侧大脑半球网络介数中心性与射精功能的相关性  

Correlation of betweenness centrality of the right hemispheric network with ejaculatory function in premature ejaculation patients

作　　者：陈建淮 黄新飞 戴丽琴 刘涛 姚志剑[2] 戴玉田[3] 陈赟 CHEN Jian-huai;HUANG Xin-fei;DAI Li-qin;LIU Tao;YAO Zhi-jian;DAI Yu-tian;CHEN Yun(Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210029, China;Department of Psychiatry, Nanjing Brain Hospital, Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China;Department of Andrology,Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008 , China)

机构地区：[1]南京中医药大学附属医院男科/江苏省中医院男科,江苏南京210029 [2]南京医科大学附属南京脑科医院精神科,江苏南京210029 [3]南京大学医学院附属南京鼓楼医院男科,江苏南京210008

出　　处：《中华男科学杂志》2019年第7期613-618,共6页National Journal of Andrology

基　　金：国家自然科学基金(81571430,81701433,81871154);南京市医学科技发展项目(YKK17098,ZKX16043)~~

摘　　要：目的:通过对早泄患者脑白质网络节点与边的介数中心性(BC)拓扑属性值的探讨,分析关键脑区及脑区间白质结构连接重要性与患者射精功能的相关性。方法:收集18例早泄患者和22例年龄、学历匹配的正常对照者的一般人口学及临床资料,并采集其大脑T1相结构数据与弥散张量成像(DTI)扫描数据;预处理所有被试T1与DTI数据,使用解剖学自动标记模板(AAL)将大脑分割为90个左右对称的皮质与皮质下区域(定义为脑网络节点),并通过概率性脑白质纤维追踪技术计算不同脑区之间的结构连接(定义为脑网络节点之间的边),同时基于脑连接工具箱(BCT)计算被试脑白质网络节点与边的介数中心性拓扑属性值,最后对节点与边介数中心性属性值进行组间Mann-Whitney U检验,并对统计结果进行错误发现率(FDR)校正,同时对组间差异属性值和患者射精功能进行Pearson相关性分析。结果:①患者组脑白质网络右侧枕上回介数中心性属性值较对照组显著下降(67.78±58.98 vs 281.18±255.26,Z=-3.49,校正后P<0.05)。②患者组脑白质网络右侧颞上回介数中心性属性值较对照组显著上升(557.00±322.65 vs 222.91±155.60,Z=3.55,校正后P<0.05)。③患者右侧罗兰多壳盖与右侧脑岛之间白质结构连接介数中心性属性值较对照组显著上升(23.83±23.91 vs 4.23±8.39,Z=3.84,校正后P<0.05)。④患者组右侧枕上回介数中心性属性值与其性生活时延迟射精的困难程度评分呈负相关(r=-0.51,P=0.03),与其射精发生在想射精之前几率呈负相关(r=-0.61,P=0.01);患者组右侧颞上回介数中心性属性值与其射精太早困扰程度评分呈正相关(r=0.54,P=0.02),与其担心射精时间可能让配偶不满程度评分(r=0.47,P=0.04)呈正相关。结论:早泄患者右侧大脑半球与视觉、情绪相关的皮质出现结构连接的紊乱,其可能参与患者射精过快或射精控制力下降症状的发生,同时可能�Objective: To explore the topological properties of the betweenness centrality of the nodes and edges in the brain white matter network of premature ejaculation(PE) patients and analyze the correlation of the importance of the key brain regions and interregional white matter structural connectivity with the ejaculatory function of the patients. Method: We collected the demographic and clinical data, along with the T1 and MR diffusion tensor imaging(MR-DTI) data, on 18 PE patients and 22 normal controls matched in age, sex and education. After preprocessing of the data obtained, we divided the whole brain into 90 symmetrical cortical and subcortical regions(defined as nodes of the brain network) by automated anatomical labeling, examined the structural connectivity between different brain regions by probabilistic white matter fiber tracking(defined as edges of the brain network), and calculated the betweenness centrality of the nodes and edges using the brain connection toolbox. Then, we performed the Mann-Whitney U test on the betweenness centrality of the nodes and edges, subjected the results to false discovery rate(FDR) correction, and assessed the correlation of the attribute values of between-group differences with the ejaculatory function of the patients. Results: Compared with the normal controls, the PE patients showed a significantly decreased betweenness centrality of the right superior occipital gyrus(SOG)(281.18 ± 255.26 vs 67.78 ± 58.98, Z =-3.49, FDR-corrected P < 0.05), but increased betweenness centrality of the right superior temporal gyrus(STG)(222.91 ± 155.60 vs 557.00 ± 322.65, Z = 3.55, FDR-corrected P < 0.05) and betweeness centrality of the edge between the right rolandic operculum and right insula(4.23 ± 8.39 vs 23.83 ± 23.91, Z = 3.84, FDR-corrected P < 0.05). The betweenness centrality of the right SOG was correlated negatively with the level of difficulty in delaying ejaculation(r =-0.51, P = 0.03) and the probability of ejaculation before expectation(r=-0.61, P = 0.01), while tha

关 键 词：早泄 射精 弥散张量成像 脑网络 右大脑半球 介数中心性 

分 类 号：R698[医药卫生—泌尿科学]