呼出气一氧化氮、儿童哮喘控制测试、肺功能与儿童支气管哮喘病情关系的研究  

Correlation among fractional exhaled nitric oxide, child asthma control test, lung function and disease severity in children with asthmatic

作　　者：孙彩虹[1] 刘晓萌[1] 姜勇[2] 刘静[1] 王冲[1] 杨召川[1] 曲政海[1] Sun Caihong;Liu Xiaomeng;Jiang Yong;Liu Jing;Wang Chong;Yang Zhaochuan;Qu Zhenghai(Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qingdao 266003, China;Department of Pediatrics, Maternity and Child Health Care of Zaozhuang, Shandong Zaozhuang 277100, China)

机构地区：[1]青岛大学附属医院儿科,266003 [2]山东省枣庄市妇幼保健院儿科,277100

出　　处：《中国医师进修杂志》2019年第8期682-685,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的通过研究支气管哮喘患儿呼出气一氧化氮(FeNO)浓度的变化,并与肺功能和儿童哮喘控制测试(C-ACT)量表进行比较,探讨三者与儿童支气管哮喘不同病情分期的关系。方法选取青岛大学附属医院2016年6月至2018年9月108例不同分期的支气管哮喘患儿,分别为急性发作期47例(47.44%),慢性持续期40例(40.37%),临床缓解期21例(21.19%)。对患儿进行FeNO检测的同时,并进行肺功能检测及C-ACT量表调查。结果慢性持续期患儿FeNO水平与急性发作期比较差异无统计学意义[(44.18±25.47)×10^-9比(46.98±27.50)×10^-9](P>0.05),临床缓解期患儿FeNO水平明显降低[(24.43±10.71)×10^-9],与急性发作期、慢性持续期患儿比较差异有统计学意义(P<0.01)。各期哮喘患儿C-ACT量表评分比较差异有统计学意义(P<0.01),组间比较差异也有统计学意义(P<0.01)。肺功能指标测定表明,急性发作期用力呼气峰流速实测值占预计值百分比(PEF%)、第1秒用力呼气容积实测值占预计值百分比(FEV1%)和第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)与慢性持续期和临床缓解期比较差异均有统计学意义(P<0.01);临床缓解期与慢性持续期PEF%、FEV1%和FEV1/FVC水平比较差异无统计学意义(P>0.05)。结论与肺功能相关指标、C-CAT量表比较,FeNO浓度更能反映支气管哮喘患儿慢性持续期以及临床缓解期气道炎性反应的变化。Objective To investigate the correlation among fractional exhaled nitric oxide(FeNO), child asthma control test(C-ACT) and lung function in asthmatic children and its clinical significance. Methods A total of 108 cases of asthmatic children in the Affiliated Hospital of Qingdao University from June 2016 to September 2018 were recruited. Forty-seven cases (47.44%) were in acute onset, 40 cases(40.37%) were in chronic persistent, and 21 cases (21.19%) were in paracmasis. FeNO, lung function and C-ACT score were measured, and the correlation among them was analyzed. Results The level of FeNO in acute onset patients and chronic persistent patients had no significant difference:(44.18 ± 25.47)× 10^-9 vs.(46.98 ± 27.50)× 10^-9, P > 0.05, but the level of FeNO in paracmasis patients was lower [(24.43 ± 10.71)× 10^-9], compared with that of acute onset patients and chronic persistent patients, there were significant differences (P < 0.01). The scores of C-ACT in three groups had significant difference (P < 0.01), and there were significant differences between any two groups (P < 0.01). The levels of forced expiratory peak flow rate measured value as a percentage of predicted value (FEV1%) and forced expiratory volume and forced vital capacity ratio in the first second (FEV1/FVC) in acute onset patients were significantly lower than those in chronic persistent patients and paracmasis patients (P <0.01), and there were no significant differences between chronic persistent patients and paracmasis patients (P>0.05). Conclusions Compared with lung functions and C-ACT, FeNO is a good biomarker to evaluate the airway inflammation of asthmatic children.

关 键 词：支气管哮喘 儿童 呼出气一氧化氮 肺功能检测 哮喘控制测试 

分 类 号：R725.6[医药卫生—儿科]