56例芬太尼药物不良反应的特点分析  

Analysis of the characteristics of adverse drug reactions of fentanyl in 56 cases

作　　者：蔡乐[1] 王诗卉[1] 司徒伟[1] 苏晔[1] 张东肃 康怡 CAI Le;WANG Shi-hui;SITU Wei;SU Ye;ZHANG Dong-su;KANG Yi(Department of Pharmacy, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院药事部

出　　处：《中国临床药理学杂志》2019年第15期1686-1688,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的分析芬太尼所致药物不良反应的发生特点及规律,为临床安全用药提供参考。方法用回顾性研究方法,收集公开发表在中国知网、万方数据库和维普数据库中有关芬太尼药物不良反应文献报道46篇,共计56例。按照患者性别、年龄、药物不良反应累及系统和(或)器官及临床表现、转归等情况进行统计分析。结果 56例芬太尼药物不良反应中,男性30例(占53. 57%),女性26例(占46. 42%),平均年龄49. 73岁。药物不良反应累及系统和(或)器官最多的为心肺功能损害,共28例(占49. 12%),其次为循环系统损害,共9例(占15. 79%);其中,好转52例(占92. 86%),死亡3例(占5. 36%),其他严重药物不良反应1例(占1. 78%)。结论芬太尼所致药物不良反应临床表现多样,临床应用应提高警惕,避免严重药物不良反应发生,加强用药监护,保证用药安全。Objective To analyze the occurrence characteristics and regularity of adverse drug reactions induced by fentanyl,so as to provide reference for clinical safe drug use. Methods A retrospective study was conducted to collect 46 literature reports on fentanyl adverse drug reac- tions published on CNKI,Wanfang database and VIP database,totaling 56 cases. Statistical analysis was conducted according to patients’gen- der,age,adverse drug reactions involved system and/or organs,clinical manifestations and outcomes. Results Among the 56 cases of fentanyl adverse drug reactions,30 cases ( 53. 57%) were male and 26 cases ( 46. 42%) were female,with an average age of 49. 73 years. Cardiores- piratory impairment was the most common cause of adverse drug reactions involving the system and/or organs,with 28 cases ( 49. 12%),followed by circulatory impairment,with 9 cases ( 15. 79%). Among them,there were 52 cases of improvement ( 92. 86%),3 cases of death ( 5. 36%), and 1 case of other severe adverse drug reactions ( 1. 78%). Conclusion The clinical manifestations of fentanyl - induced adverse drug reactions varied,and to ensure drug safetyand avoid serious adverse drug reac- tions,the clinical application should be vigilant anddrug monitoring needs to be strengthened.

关 键 词：芬太尼 药物不良反应 合理用药 

分 类 号：R971.2[医药卫生—药品]