过氧化物酶体增殖物激活受体-α信号通路在心力衰竭中作用的研究现状  

Research status on the role of peroxisome proliferator-activated receptor alpha signaling pathway in heart failure

作　　者：李洁[1,2] 李澜 倪晶宇 樊官伟 LI Jie;LI Lan;NI Jing-yu;FAN Guan-wei(University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin Key Laboratory of Translational Research of Traditional Chinese Medicine Prescription and Syndrome,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院医学实验中心,天津300193 [2]天津市中医方证转化研究重点实验室,天津300193

出　　处：《中国临床药理学杂志》2019年第15期1699-1702,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81774050);天津市杰出青年科学基金资助项目(17JCJQJC46200);天津市自然科学基金资助项目(17CYBJC29000)

摘　　要：过氧化物酶体增殖物激活受体-α(PPAR-α)在调节心脏脂肪酸摄取和氧化的基因的转录控制中具有重要作用。PPAR-α是维持心肌线粒体完整性的重要靶标,也是葡萄糖的摄取、氧化,以及脂质的代谢等能量代谢调控中重要的调节因子。同时,PPAR-α通过在基因转录水平上对能量代谢的调节,在心肌细胞的能量代谢紊乱、缺血性心肌病和心力衰竭等心血管疾病的发生发展中发挥重要作用。本文围绕PPAR-α信号通路在心力衰竭中的作用做一简要综述。Peroxisome proliferator - activated receptor alpha ( PPAR -α) plays an important role in the transcriptional control of genes. PPAR -α is an important target for maintaining myocardial mitochondrial integrity, and is also an important regulator of energy metabolism regulation such as glucose uptake,oxidation,and lipid metabolism. At the same time, PPAR -α plays an important role in the development of cardiovascular diseases such as myocardial cell energy metabolism disorder,ischemic cardiomyopathy,and heart failure by regulating energy metabolism at the level of gene transcription. Therefore,this article focuses on the role of PPAR -α signaling pathway in heart failure.

关 键 词：过氧化物酶体增殖物激活受体-Α 心肌能量代谢紊乱 心肌病 心力衰竭 

分 类 号：R97[医药卫生—药品]