靶向星形胶质细胞治疗缺血性脑卒中的研究进展  

The research on regulating astrocyte protection function after ischemic stroke

作　　者：陈华波 黄艳丽[2] 翟立红[1] 沈小芳 毛春[2] 李通 肖娟[1] CHEN Hua-Bo;HUANG Yan-Li;ZHAI Li-Hong;SHEN Xiao-Fang;MAO Chun;LI Tong;XIAO Juan(Department of Molecular Medicine Laboratory,Hubei University of Arts and Science,Xiangyang 441053,China;Xiangyang Central Hospital,Hubei University of Arts and Science,Xiangyang 441021,China)

机构地区：[1]湖北文理学院分子医学实验室,襄阳441053 [2]湖北文理学院附属襄阳市中心医院,襄阳441021

出　　处：《生命科学》2019年第7期671-677,共7页Chinese Bulletin of Life Sciences

基　　金：湖北省教育厅科学技术研究项目(D20172603);湖北文理学院临床医学重点学科基金

摘　　要：缺血性脑卒中(ischemic stroke, IS)发生后,缺血区星形胶质细胞(astrocyte)活化,这些反应性星形胶质细胞对缺血区神经元发挥有利和有害双重作用。星形胶质细胞与IS诱导的谷氨酸功能障碍、线粒体功能障碍和胶质瘢痕形成密切相关,并且在IS后神经元网络重构中发挥重要调节作用。现重点探讨如何利用星形胶质细胞对IS发挥保护作用的研究进展。Astrocytes are activated after ischemic stroke(IS). The astrocytes play both deleterious and beneficial roles in ischemic area. Astrocytes are involved in extracellular glutamate dysfunction, mitochondrial dysfunction and glial scar formation, and play an important regulatory role in neuronal network remodeling after IS. In this review, we will focus on the recent progresses regarding to the protection function of astrocytes in IS.

关 键 词：缺血性脑卒中 星型胶质细胞 保护 

分 类 号：Q42[生物学—神经生物学] R741[生物学—生理学]