猪源产肠毒素性大肠杆菌主要毒力因子研究进展  

Research progress on the main virulence factors of enterotoxin-producing Escherichia coli from pigs

作　　者：吴文文 丁雪燕 洪天旗 羊扬[1,2] 段强德 朱国强[1,2] WU Wen-wen;DING Xue-yan;HONG Tian-qi;YANG Yang;DUAN Qiang-de;ZHU Guo-qiang(College of Veterinary Medicine,Yangzhou University,Yangzhou,Jiangsu 225009,China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou,Jiangsu 225009,China)

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009

出　　处：《中国兽医学报》2019年第7期1403-1409,共7页Chinese Journal of Veterinary Science

基　　金：科技部畜禽重大疫病防控与高效安全养殖综合技术研发重点专项资助项目(2016YFD0500905,2017YF-D050-0105);江苏高校优势学科建设工程资助项目;江苏自然科学基金资助项目(BK20150442);国家自然科学基金资助项目(31502075,31672579,31873010)

摘　　要：产肠毒素性大肠杆菌(enterotoxigenic Escherichia coli,ETEC)是引起婴幼儿和幼畜腹泻的主要细菌性病原,初生幼畜感染后常因剧烈腹泻脱水而死亡。菌毛黏附素和肠毒素是ETEC目前研究最多的2类毒力因子,随着技术手段的不断进步和研究的深入,一些新型毒力因子不断被发现,如鞭毛、非菌毛黏附素、肠聚集性耐热毒素(the enteroaggregative heat-stable toxin1,EAST1)、自转运黏附蛋白、细胞溶血素等。本综述主要针对猪源ETEC的主要毒力因子以及新型毒力的结构功能及致病性进行阐述,为进一步深入探索ETEC的致病机理提供理论基础。Enterotoxigenic Escherichia coli(ETEC)is the main bacterial pathogen that causes diarrhea in infants and young animals.Newborn animals often die from severe diarrhea after infection. ETEC fimbriae and enterotoxin are the two most virulence factors studied.With the development of the technical means and in-depth research,some new virulence factors have been discovered, such as flagella,non-fimbriae adhesion,enteroaggregative heat-stable toxin1(EAST1),etc.The review focuses on structure,function and pathogenesis of the main virulence factors and some new virulence factors of ETEC,in order to provide the theoretical basis for further exploration of the pathogenic mechanism of ETEC.

关 键 词：产肠毒素大肠杆菌 黏附素 肠毒素 毒力因子 

分 类 号：S852.61[农业科学—基础兽医学]