白念珠菌生物被膜治疗研究进展  

Research progress of the treatment of biofilms of Candida albicans

作　　者：姜佳玉 王汐文 唐希远 陈丽华 Jiang Jia-yu;Wang Xi-wen;Tang Xi-yuan;Chen Li-hua(Department of Examination, Xiangya Medical College, Central South University, Changsha 410013;Department of Anesthesiology, Xiangya Medical College, Central South University, Changsha 410013)

机构地区：[1]中南大学湘雅医学院检验系,长沙410013 [2]中南大学湘雅医学院麻醉系,长沙410013

出　　处：《中国抗生素杂志》2019年第8期899-903,共5页Chinese Journal of Antibiotics

基　　金：湖南省卫生健康委科研计划课题项目(No.C2019167);中南大学研究性学习和创新性实验计划(No.YC20180673)

摘　　要：白念珠菌是一种临床常见的条件致病菌,当其形成生物被膜后可以形成保护膜,抵抗抗真菌药物的作用和避免宿主免疫系统攻击,将会造成难治性感染,给人类健康带来严重的威胁。因此,探究白念珠菌生物被膜的治疗方法具有重要的意义。本文从多种药物治疗,生物医学材料的改进等方面综述了白念珠菌生物被膜治疗的最新进展,旨在为白念珠菌感染的临床防治提供参考。Candida albicans is a common clinical opportunistic pathogen. When it forms a biofilm, it can form a protective film to resist the activity of antifungal drugs and avoid the attack of host immune system, which causes refractory infections and poses a serious threat to human health. Therefore, it is of great significance to explore the treatment of Candida albicans biofilm. This article reviews the latest progress in biological coating treatment of Candida albicans from various drug treatments and improvement of biomedical materials, which may be useful for clinical prevention and treatments of Candida albicans infections.

关 键 词：白念珠菌 生物被膜 治疗 抗真菌药物 生物材料的改良 

分 类 号：R379.4[医药卫生—病原生物学]