哮喘预测指数在乌市婴幼儿喘息性疾病中的应用研究  

Application of asthma prediction index in asthma diseases of infants and young children in Urumqi city

作　　者：顾晓丽[1] 陈芳[1] GU Xiao-Li;CHEN Fang(Department of Pediatrics,The Second Affiliated Hospital,Xinjiang Medical University,Urumqi 830063,China)

机构地区：[1]新疆医科大学第二附属医院儿科

出　　处：《中国处方药》2019年第9期165-166,共2页Journal of China Prescription Drug

基　　金：新疆医科大学科研创新基金项目(XYDCX201632)

摘　　要：目的研究哮喘预测指数(API)在乌市婴幼儿喘息性疾病中的应用效果。方法选取2017年1月~12月在某院儿科住院部所有符合入选标准签署知情同意书的患儿共246例,根据API分为阳性与阴性组,其中阳性组102例,阴性组144例,所有患儿入院24h内均对其进行呼出气一氧化氮(FeNO)浓度、嗜酸性粒细胞比率(EOS%)、血清总免疫球蛋白E(IgE)检测,收集相关实验室检查数据,对比阳性组与阴性组患儿各项指标的检测结果,并分析阳性组患儿FeNO与EOS%、IgE之间的相关性;同时对两组患儿进行常规一线治疗,出院后随访3~6个月,统计患儿再发哮喘的几率,并对比阳性组与阴性组患儿再发哮喘几率的差异性。结果阳性组患儿的FeNO、EOS%、IgE检测结果均高于阴性组,差异有统计学意义(P<0.05);多因素Pearson线性相关分析结果显示,FeNO与EOS%、IgE均呈正相关性(r=0.851、0.759,均P<0.05);随访结果显示,246例患儿出院后再发哮喘39例,复发率为15.9%,其中包括阳性组23例,阴性组16例,阳性组患儿出院后再发哮喘的几率(22.5%)高于阴性组(11.1%),差异有统计学意义(P<0.05)。结论哮喘预测指数在乌市婴幼儿喘息性疾病的应用效果显著,可指导该病的临床诊断与治疗,对提高患儿的治疗效果与预后具有重要意义。Objective To study the application effect of asthma prediction index(API)in asthmatic diseases of infants and young children in Wushi.Methods From January to December 2017,246 children who met the admission criteria and signed the informed consent form were selected.According to API,they were divided into positive and negative groups,including 102 children in positive group and 144 children in negative group.All children were given exhaled nitric oxide(FeNO)concentration and eosinophils within 24 hours of admission.The ratio(EOS%)and serum total immunoglobulin E(IgE)were detected.The data of laboratory tests were collected.The results of various indicators were compared between the positive group and the negative group,and the correlation between FeNO,EOS%and IgE in the positive group was analyzed.At the same time,the two groups were given routine first-line treatment and followed up for 3 to 6 months after discharge.The incidence of recurrent asthma in children was counted,and the difference between positive group and negative group was compared.Results The results of FeNO,EOS%and IgE in positive group were higher than those in negative group;Pearson linear correlation analysis showed that FeNO was positively correlated with EOS%and IgE(r=0.851,0.759,P<0.05).The follow-up results showed that 39 of 246 children with asthma recurred after discharge,with a recurrence rate of 15.9%,including 23 in the positive group and 16 in the negative group.The recurrence rate of asthma in the positive group(22.5%)was higher than that in the negative group(11.1%).Conclusion The application of asthma prediction index in asthmatic diseases of infants and young children in Wushi City is significant,which can guide the clinical diagnosis and treatment of asthmatic diseases,and has important significance for improving the treatment effect and prognosis of children with asthma.

关 键 词：哮喘预测指数 乌市 婴幼儿 喘息性疾病 

分 类 号：R725.6[医药卫生—儿科]