不同输卵管病变不孕症患者IVF-ET妊娠结局分析  

Analysis of pregnancy outcomes of IVF-ET in infertility patients with different fallopian tube diseases

作　　者：徐玉萍[1,2,3] 王超 姜小花[1,2,3] 张曼雨 王新宇 邢琼 倪小晴 曹云霞[1,2,3] Xu Yuping;Wang Chao;Jiang Xiaohua(Reproductive Medicine Center, Dept of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022;Anhui Province Key Laboratory of Reproductive Health and Genetics, Hefei 230022;Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖医学中心,合肥230022 [2]安徽医科大学生殖健康与遗传安徽省重点实验室,合肥230022 [3]安徽省生命资源保存与人工器官工程技术研究中心,合肥230022 [4]安徽医科大学第一临床医学院,合肥230032

出　　处：《安徽医科大学学报》2019年第9期1462-1466,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽高校自然科学研究项目(编号:KJ2018A0190)

摘　　要：目的比较体外受精-胚胎移植(IVF-ET)助孕前不同输卵管病变患者对控制性促排卵过程中促性腺激素(Gn)的反应效果及胚胎移植结局的差异。方法回顾性分析 1 148 例行首次IVF-ET助孕的仅输卵管因素不孕症患者的临床资料,分为3组:输卵管切除组(306例)、堵塞组(708例)及积水组(134例)。新鲜周期胚胎移植患者共187例,首次复苏周期胚胎移植患者共872例。结果三组患者Gn使用量及天数、获卵数、囊胚数、新鲜周期及首次复苏周期的胚胎着床率、妊娠率差异均无统计学意义( P >0.05)。输卵管切除组的正常受精率(62.76%)及囊胚形成率(38.88%)显著高于输卵管堵塞组(60.10%,34.73%)( P <0.0167),而输卵管切除组与积水组及堵塞组与积水组在上述两个指标方面差异无统计学意义( P >0.0167)。结论输卵管切除、堵塞及积水患者IVF-ET助孕过程中对Gn反应效果相当,且不论新鲜周期还是复苏周期胚胎移植,具有相似的胚胎移植结局。Objective To compare the response on gonadotropin (Gn) and the outcomes of embryo transfer in patients with different fallopian tube diseases before in vitro fertilization-embryo transfer(IVF-ET). Methods The clinical data of 1 148 infertility patients with only tubal factors who accepted the first IVF-ET were retrospectively analyzed. There were divided into 3 groups:the salpingectomy group (306 cases), the occlusion group (708 cases) and the hydrosalpinx group (134 cases). A total of 187 patients accepted fresh embryo transfer and 872 patients accepted frozen embryo transfer for the first time. Results There were no significant differences in Gn usage, Gn days, number of oocytes and embryos, implantation rate and pregnancy rate between the 3 groups ( P >0.05). The normal fertilization rate (62.76%) and blastocyst formation rate (38.88%) in the salpingectomy group were significantly higher than those in the occlusion group (60.10%, 34.73%)( P <0.016 7). However, the differences of these 2 indicators were not significant between the comparison of salpingectomy group with hydrosalpinx group and the comparison of occlusion group with hydrosalpinx group ( P >0.016 7). Conclusion Patients with salpingectomy, occlusion and hydrosalpinx display comparable Gn response and similar embryo transfer outcomes regardless of fresh or frozen embryo transfer cycle.

关 键 词：输卵管 切除 堵塞 积水 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]