粪便潜血试验及粪便DNA检测对结直肠癌筛查的比较研究  

Comparison of the effectiveness of three fecal occult blood tests and digital immunoassay combined fecal DNA test on screening of colorectal cancer

作　　者：金水 王亚雷[1] 衡苗[1] 李仁君 路亮 朱道明[2] 方海明[3] Jin Shui;Wang Yalei;Heng Miao(Dept of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022;Dept of Gastroenterology, Chaohu Affiliated Hospital of Anhui Medical University, Chaohu 238000)

机构地区：[1]安徽医科大学第一附属医院消化内科,合肥230022 [2]安徽医科大学附属巢湖医院消化内科,巢湖238000 [3]安徽医科大学第二附属医院消化内科,合肥230601

出　　处：《安徽医科大学学报》2019年第9期1485-1489,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽省公益性技术应用研究联动计划项目(编号:15011d04043)

摘　　要：选取244例患者为研究对象,比较胶体金法、噗噗管法、数值化免疫法和数值化免疫法联合粪便DNA(FIT-DNA)法在结直肠疾病筛选中的差异。结果显示,FIT-DNA法在鉴别结直肠癌(CRC)、癌前病变和高危腺瘤方面的敏感度和阳性率均显著高于其他方法;其对正常大肠和其他性质病变的假阳性率显著低于其他3种方法。表明FIT-DNA法可以作为筛查结直肠病变的首选工具。To compare the differences of fecal immunocolloidal gold test, poop-poop tube test, digital immunoassay and fecal immunochemical test combined with DNA test(FIT-DNA) for screening of colorectal cancer diseases. A total of 244 patients were enrolled. The sensitivity and positive values of FIT-DNA test in the identification of colorectal cancer, precancerous lesions and high-risk adenomas were significantly higher than those of the other three tests;The false positive value of normal intestine and other lesions was significantly lower than those of the other three tests. FIT-DNA can be used as the first choice for screening of colorectal diseases.

关 键 词：数值化免疫法联合粪便DNA 结直肠癌 高危腺癌 

分 类 号：R446.13[医药卫生—诊断学]