白细胞介素-1β、白细胞介素-8及肿瘤坏死因子-α与房颤伴凝血功能异常的相关性  

Correlation between interleukin-1β, interleukin-8, tumor necrosis factor-α and atrial fibrillation with abnormal coagulation function

作　　者：戴艳枝[1] 王晓华[2] 刘秋玲[3] 张淑华[3] 周云英[4] 文丽丹 杨海玉[5] DAI Yan-zhi;WANG Xiao-hua;LIU Qiu-ling;ZHANG Shu-hua;ZHOU Yun-ying;WEN Li-dan;YANG Hai-yu(Department of Pathology,Jiangxi Provincial People′s Hospital,Nanchang 330006,China;Department of Cardiovascular Medicine,Jiangxi Provincial People′s Hospital,Nanchang 330006,China;Institute of Cardiovascular Research,Jiangxi Provincial People′s Hospital,Nanchang 330006,China;Intervention Room,Jiangxi Provincial People′s Hospital,Nanchang 330006,China;Institute of Clinical Medicine Research,Jiangxi Provincial People′s Hospital,Nanchang 330006,China)

机构地区：[1]江西省人民医院病理科,江西南昌330006 [2]江西省人民医院心血管内科,江西南昌330006 [3]江西省人民医院心血管研究所,江西南昌330006 [4]江西省人民医院介入室,江西南昌330006 [5]江西省人民医院临床医学研究所,江西南昌330006

出　　处：《中国当代医药》2019年第23期4-7,共4页China Modern Medicine

基　　金：江西省科技厅社会发展领域重点项目(20135BBG70008)

摘　　要：目的研究白细胞介素-1β(IL-1β)、白细胞介素8(IL-8)及肿瘤坏死因子-α(TNF-α)与心房颤动(房颤)伴凝血功能异常的关系。方法选取2016年1月~2017年12月我院收治的42例房颤患者作为房颤组,其中阵发性房颤14例,持续性房颤28例,另选取同期门诊体检的20例健康者作为对照组。采用酶联免疫法检测各组的血浆IL-1β、IL-8、TNF-α水平,分析其与房颤类型、凝血功能参数及血常规参数的相关性。结果房颤组与对照组的IL-1β水平比较,差异无统计学意义(P>0.05);房颤组的IL-8、TNF-α水平均明显高于对照组,差异有统计学意义(P<0.05)。阵发性房颤组、持续性房颤组、对照组的IL-1β水平比较,差异无统计学意义(P>0.05);阵发性房颤组、持续性房颤组的IL-8及TNF-α水平均明显高于对照组,差异有统计学意义(P<0.05)。不同凝血酶原时间、国际标准化比值情况下的IL-1β、IL-8、TNF-α水平比较,差异无统计学意义(P>0.05);凝血酶时间>16s患者的IL-1β、TNF-α水平均明显高于凝血酶时间≤16s(正常)患者,差异有统计学意义(P<0.05)。IL-1β、TNF-α水平与白细胞计数、红细胞计数、血小板计数、中性粒细胞百分比、淋巴细胞百分比、单核细胞百分比均无相关性(P>0.05);IL-8水平与淋巴细胞百分比成正相关(r=0.314,P<0.05)。结论IL-8及TNF-α水平在房颤患者中增高,提示其可能与房颤发生相关;IL-1β、TNF-α水平增高与房颤伴凝血功能异常相关。Objective To study the relationship between interleukin-1β(IL-1β),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and atrial fibrillation with abnormal coagulation function.Methods A total of 42 patients with atrial fibrillation admitted to our hospital from January 2016 to December 2017 were selected as the atrial fibrillation group,including 14 patients with paroxysmal atrial fibrillation,28 patients with persistent atrial fibrillation,and 20 healthy subjects who underwent physical examination at the same time were selected as the control group.The levels of IL-1β,IL-8 and TNF-αin plasma were detected by enzyme linked immunosorbent assay,and their correlation with atrial fibrillation type,coagulation function parameters and blood routine parameters were analyzed.Results There was no significant difference in IL-1βlevel between the atrial fibrillation group and the control group(P>0.05).The levels of IL-8 and TNF-αin the atrial fibrillation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in IL-1βlevel between paroxysmal atrial fibrillation group,persistent atrial fibrillation group and control group(P>0.05).The levels of IL-8 and TNF-αin paroxysmal atrial fibrillation group and persistent atrial fibrillation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of IL-1β,IL-8 and TNF-αbetween different prothrombin time and international normalized ratio(P>0.05).The levels of IL-1βand TNF-αin patients with thrombin time>16 s were significantly higher than those with thrombin time≤16 s(normal),and the differences were statistically significant(P<0.05).There was no correlation between IL-1β,TNF-αlevels and white blood cell count,red blood cell count,platelet count,neutrophil percentage,lymphocyte percentage,and monocyte percentage(P>0.05).The IL-8 level was positively

关 键 词：白细胞介素-1Β 白细胞介素8 肿瘤坏死因子-Α 心房颤动 凝血功能 

分 类 号：R541.75[医药卫生—心血管疾病]