东北铁线莲中皂苷类化学成分研究  

Study on triterpenoid glycosides from roots of Clematis manshurica

作　　者：王洁雪 李秉轲 杨敏 杜琳 陈聪地 杨帆 杨鸿均[2] WANG Jie-xue;LI Bing-ke;YANG Min;DU Lin;CHEN Cong-di;YANG Fan;YANG Hong-jun(College of Chemistry and Life Science,Chengdu Normal University,Chengdu 611130,China;College of Chemistry & Environment Protection Engineering,Southwest Minzu University,Chengdu 610041,China)

机构地区：[1]成都师范学院化学与生命科学学院功能分子研究所,四川成都611130 [2]西南民族大学化学与环境保护工程学院,四川成都610041

出　　处：《中草药》2019年第16期3753-3759,共7页Chinese Traditional and Herbal Drugs

基　　金：四川省科技厅项目(2019YJ0440);四川省教育厅项目(18ZB0097);四川省大学生创新创业训练(201814389068)

摘　　要：目的研究东北铁线莲Clematis manshurica的化学成分。方法采用硅胶柱色谱、凝胶色谱及高压制备色谱等方法对东北铁线莲的三萜皂苷类成分进行分离纯化,并通过其理化性质及波谱数据对分离得到的化合物进行结构表征。结果从东北铁线莲中共分离得到10个齐墩果烷型三萜皂苷类化合物,分别鉴定为威灵仙皂苷L(1)、clematichinenoside A(2)、clematochinenoside F(3)、clematernoside A(4)、clematichinenoside B(5)、clematichinenoside C(6)、clematomandshurica saponin B(7)、clematomandshurica saponin D(8)、clematomandshurica saponin C(9)、huzhangoside B(10)。结论化合物1为新的三萜皂苷类化合物,2~6为首次从该植物中分离得到。Objective To study the chemical constituents from the roots of Clematis manshurica.Methods Ten compounds were separated and purified by silica gel,Sephadex LH-20,and preparative HPLC.The structures were identified by physicochemical properties and spectral analyses.Results A total of ten oleanane-type triterpenoid saponins were isolated and identified as clematomandshurica saponin L(1),clematichinenoside A(2),clematochinenoside F(3),clematernoside A(4),clematichinenoside B(5),clematichinenoside C(6),clematomandshurica saponin B(7),clematomandshurica saponin D(8),clematomandshurica saponin C(9),and huzhangoside B(10),respectively.Conclusion Compound 1 is a new oleanane-type triterpenoid glycoside,and compounds 2-6 are isolated from this plant for the first time.

关 键 词：威灵仙 东北铁线莲 齐墩果烷型 三萜皂苷 威灵仙皂苷L clematichinenoside A clematochinenoside F 

分 类 号：R284.1[医药卫生—中药学]