基于脑电反馈训练改善轻度认知功能障碍综合症的脑功能状态研究  

Improvement of brain function in mild cognitive dysfunction syndrome based on EEG feedback training

作　　者：李向东 安占周 王佳名 李宏兵 马峥 曹凯 张晓红 李昕[2] Li Xiangdong;An Zhanzhou;Wang Jiaming;Li Hongbing;Ma Zheng;Cao Kai;Zhang Xiaohong;Li Xin(HUISIANPU Medical System Incorporated Company, Qinhuangdao 066000;Institute of Biomedical Engineering, Yanshan University, Qinhuangdao, Hebei 066004)

机构地区：[1]惠斯安普医学系统股份有限公司,秦皇岛066000 [2]燕山大学电气工程学院生物医学工程研究所,秦皇岛066004

出　　处：《高技术通讯》2019年第8期816-822,共7页Chinese High Technology Letters

基　　金：国家自然科学基金(51677162);中国博士后科学基金(2014M550582);河北省自然科学基金(F2019203515)资助项目

摘　　要：阿尔茨海默病(AD)作为典型的脑功能障碍性疾病,严重影响患者的工作与生活。轻度认知功能障碍综合症(MCI)作为阿尔茨海默病的前期症状,对其干预治疗对延缓病情具有重要作用。本文基于记忆力障碍训练仪中的意念力游戏训练系统对20名确诊的轻度认知功能障碍患者进行干预治疗,采集其脑电信号,提取并分析近似熵和相干性两种脑电特征。结果表明:两个疗程干预后的脑电信号近似熵与相干性均高于干预前,且除近似熵的F3、F8通道和相干性的F3-F4和T3-T4两组对应通道外,其余均具有显著性差异( P < 0.05)。由此得出记忆力障碍训练仪对轻度认知障碍的干预训练增大了脑电近似熵与对应通道相干性,提高了脑电复杂性,增强了脑电信号(EEG)同步性,能够改善轻度认知障碍症状,且具有显著效果的结论。Alzheimer’s disease(AD) is a typical disease of brain dysfunction, which seriously affects the work and life of patients. Intervention for mild cognitive impairment(MCI) which is the early symptoms of Alzheimer’s disease has great significance. In this study, 20 patients with mild cognitive impairment are treated with a new mind game training system based on memory disorder training instrument. Electroencephalogram(EEG) is collected and two EEG characteristics, ie. approximate entropy and coherence are extracted and analyzed. Results show that the values of approximate entropy(ApEn) and coherence of EEG signals after two courses of treatment are higher than those before intervention, and there are significant differences( P <0.05) between the two groups, except for the approximate entropy in F3, F8 channels and coherence in F3-F4 and T3-T4 channels. It is concluded that the intervention training of ADTS for mild cognitive impairment enhances the approximate entropy of EEG and the coherence of corresponding channels, enhances the complexity and the synchronization of EEG signals, and alleviates the symptoms of mild cognitive impairment remarkably.

关 键 词：阿尔茨海默病(AD) 轻度认知功能障碍综合症(MCI) 脑电信号(EEG) 近似熵(ApEn) 相干性 

分 类 号：TN911.7[电子电信—通信与信息系统] R749.1[电子电信—信息与通信工程]