美能对腹泻所致肝功能损害的治疗效果及其对患者免疫功能的影响  

Therapeutic effects of stronger neo-minophagen Conliver function damage caused by diarrhea and its influence on immune function of patients

作　　者：白静洁 Bai Jingjie(Department of Gastroenterology,Children's Hospital of Shanxi,Taiyuan 030000,China)

机构地区：[1]山西省儿童医院消化科,太原030000

出　　处：《中国实用医刊》2019年第14期88-91,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨美能对小儿腹泻所致肝功能损害的治疗效果及其对患者免疫功能的影响.方法将山西省儿童医院2016年6月至2018年6月收治的96例腹泻致肝功能损害患儿作为研究对象,采用随机数字表法将其分为观察组(美能+蒙脱石散+常规治疗,n=48)与对照组(肝泰乐+蒙脱石散+常规治疗,n=48),观察两组治疗效果.结果治疗后,两组肝功能指标如丙氨酸氨基转移酶、天门冬氨酸氨基转移酶及总胆红素水平均较治疗前下降(P均<0.05),且观察组治疗后以上指标水平均低于对照组(P均<0.05);观察组治疗有效率高于对照组(P<0.05);两组治疗后血清免疫球蛋白A(IgA)、IgM、IgG水平均较治疗前上升(P<0.05),且观察组治疗后血清IgA、IgM水平均高于对照组(P均<0.05);两组治疗后CD4+、CD8+及CD4+/CD8+水平均较治疗前上升(P均<0.05),且观察组治疗后CD4+水平高于对照组(P<0.05).结论美能是一种复发甘草酸类制剂,药物不良反应小,能有效保护腹泻所致肝功能损害患儿的肝脏功能,提高其机体免疫功能,治疗效果显著.Objective To explore the therapeutic effect of stronger neo-minophagen C(SNMC)on liver function damage caused by diarrhea in children and its influence on immune function of children.Methods Ninety-six children with diarrhea-induced liver dysfunction admitted to Shanxi Children’s Hospital from June 2016 to June 2018 were divided into observation group(SNMC+montmorillonite powder+routine treatment,n=48)and control group(gantaile+montmorillonite powder+routine treatment,n=48)by random number table method.The therapeutic effects of the two groups were observed.Results After treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)in the two groups were lower than those before treatment(P all<0.05),and the above indexes in the observation group were lower than those in the control group(P all<0.05).The effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The levels of serum immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)increased after treatment in both groups(P<0.05),and the levels of serum IgA and IgM in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of CD4+,CD8+and CD4+/CD8+in both groups were higher than those before treatment(P all<0.05),and the levels of CD4+in the observation group were higher than those in the control group(P<0.05).Conclusions SNMC is a recrudescent glycyrrhizic acid preparation with less adverse drug reactions.It can effectively protect the liver function of children with diarrhea-induced liver damage and improve their immune function.The therapeutic effect is remarkable.

关 键 词：美能 腹泻 肝功能损害 治疗效果 免疫功能 

分 类 号：R725.7[医药卫生—儿科]