调控静止期癌细胞预防肺癌复发转移初探  

Exploring Prevention of Recurrence and Metastasis in Lung Cancer by Regulating Quiescent Cancer Cells

作　　者：席志超[1,2] 阙祖俊 冯极灵[1,2] 田建辉[3,4] 徐宏喜 Xi Zhichao;Que Zu Jun;Feng Jiling;Tian JianHui;Xu HongXi(School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China;Longhua Hospital,Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China;Oncology Institute of Traditional Chinese Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 200032, China)

机构地区：[1]上海中医药大学中药学院,上海201203 [2]中药创新药物研发上海高校工程研究中心,上海201203 [3]上海中医药大学附属龙华医院,上海200032 [4]上海市中医药研究院中医肿瘤研究所,上海200032

出　　处：《世界科学技术-中医药现代化》2019年第5期949-955,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年项目(81803571):Guttiferone K调节线粒体核糖体蛋白选择性杀死静止期前列腺癌细胞的机理研究，负责人：席志超;国家自然科学基金委面上项目(81774166)：从免疫衰老与循环肿瘤细胞揭示肺癌发病及转移核心病机“正虚伏毒”的形成机制，负责人：田建辉;国家自然科学基金委青年项目(81803777)：重楼皂苷诱导循环肿瘤细胞失巢凋亡抑制肺癌转移的作用及机制研究，负责人：阙祖俊

摘　　要：复发转移是导致肺癌死亡的主要原因,目前尚缺乏有效的理论指导和干预措施。田建辉团队基于"扶正治癌"学术思想,融合现代肿瘤学的研究,提出"正虚伏毒"为肺癌发生发展的核心病机,其中"伏毒"指的是肿瘤病人体内的多种肿瘤细胞,包括静止期癌细胞。静止期癌细胞对放化疗不敏感且可以逃避机体免疫清除,激活后会造成肿瘤的转移和复发。徐宏喜课题组率先提出可以通过抑制静止期癌细胞激活预防肿瘤的转移和复发,建立了一系列体内外的研究模型,并发现了抑制静止期癌细胞激活的关键分子机理和活性先导化合物。静止期癌细胞的研究将为预防肺癌转移复发提供实验证据和理论支持。Recurrence and metastasis are the primary cause of mortality in lung cancer. At present, effective theoretical guidance and intervention on these causes are yet unavailable. Tian Jianhui and his team proposed"Deficiency of vital qi and hidden toxin"as the core pathogenesis in lung cancer, which stems from the"strengthening the body to treat the cancer"concept and integration with current oncology research."Hidden toxin"refers to varies types of cancer cells within cancer patients, including quiescent cancer cells(QCC). QCC are insensitive to radiotherapy and chemotherapy and additionally can evade immune system’s extermination, consequently cancer metastasis and recurrence once QCC are activated. Xu Hongxi’s research team pioneered the concept that cancer recurrence and metastasis can be prevented via suppressing the activation of QCC. They established a series of in vivo and in vitro research models as well as discovered the key molecular mechanism and active lead compounds which could effectively inhibit QCC activation. The research on QCC may provide experimental evidence and theoretical support in prevention of metastasis and recurrence in lung cancer.

关 键 词：肺癌 静止期癌细胞 转移 复发 预防 

分 类 号：R459.9[医药卫生—治疗学]