调Q脉冲激光联合甲硝唑凝胶和多西环素治疗轻中度玫瑰痤疮疗效研究  

Curative Effect of Q-switched Pulsed Laser Radiation Combined with Metronidazole Gel and Doxycycline in the Treatment of Mild to Moderate Rosacea

作　　者：李伶[1] 郭中华[1] LI Ling;GUO Zhong-hua(Department of Dermato-Venereology,Chengdu Fifth People’s Hospital,Chengdu 611130,Sichuan,China)

机构地区：[1]成都市第五人民医院皮肤性病科

出　　处：《中国美容医学》2019年第9期18-21,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨调Q脉冲激光联合甲硝唑凝胶与多西环素药物治疗玫瑰痤疮的疗效和安全性。方法:选取2015年7月-2018年9月笔者医院门诊收治的轻、中度玫瑰痤疮患者80例,采用随机数字法分为对照组(38例)和观察组(42例),其中观察组采用调Q脉冲激光联合甲硝唑凝胶和多西环素治疗,对照组采用甲硝唑凝胶外用+多西环素口服治疗。观察两组患者治疗6周后临床疗效与总体评分(investigator’s global assessment,IGA)、炎性丘疹数以及治疗前后症状积分(红斑、丘疹脓疱、瘙痒)。结果:治疗6周,观察组临床疗效显著优于对照组,组间差异具有统计学意义(P<0.05);治疗6周后,两组患者IGA评分明显下降,且观察组明显低于对照组,差异具有统计学意义(P<0.05);两组患者治疗前红斑、丘疹脓疱、瘙痒等症状积分无统计学差异(P>0.05),治疗后两组患者红斑、丘疹脓疱、瘙痒等症状积分明显转好,且观察组临床症状积分低于对照组,差异有统计学意义(P<0.05)。结论:采用调Q脉冲激光联合药物治疗玫瑰痤疮,患者临床症状明显改善,可达到理想的治疗效果。Objective To evaluate the efficacy and safety of Q-switched pulsed laser radiation combined with metronidazole gel and doxycycline in the treatment of rosacea. Methods 80 patients with mild and moderate rosacea admitted in our hospital from July 2015 to September 2018 were selected as the subjects and divided into the control group(38 cases) and the observation group(42 cases) by random number method. The observation group was treated with Q-switched pulsed laser radiation combined with metronidazole gel and doxycycline, the control group was treated with metronidazole gel for external use + doxycycline for oral therapy. The clinical efficacy, the investigator’s global assessment(IGA), the number of inflammatory papules and the score of symptoms(erythema, papule pustules, pruritus) before and after treatment were observed at six weeks after treatment. Results After 6 weeks of treatment, the clinical efficacy of the observation group was significantly better than that of the control group, and the difference between the two groups was statistically significant(P<0.05);after 6 weeks of treatment, the IGA scores of the two groups were significantly decreased, and the IGA score of the observation group was significantly lower than that of the observation group, and the difference between the two groups was statistically significant(P<0.05);there was no significant difference in the scores of erythema, papule pustule, pruritus and other symptoms before treatment between the two groups(P>0.05), after treatment, the scores of erythema, papule pustule, pruritus and other symptoms of the two groups were significantly improved, and the scores of clinical symptoms of the observation group were lower than those of the control group, and there was a significant difference between the two groups(P<0.05). Conclusion The use of Q-switched pulsed laser radiation combined with drugs on rosacea can significantly improve the clinical symptoms of patients, and achieve the desired therapeutic effect.

关 键 词：玫瑰痤疮 调Q脉冲激光 甲硝唑 多西环素 红斑 疗效 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]