结核感染T细胞检测试验的临床应用价值及研究进展  

Clinical application value and research progress of T cell detection of tuberculosis infection

作　　者：李国峰 李用国[1] LI Guofeng;LI Yongguo(Department of Infection,First Affiliated Hospital of Harbin MedicalUniversity,Harbin,Heilongjiang 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院感染科

出　　处：《国际检验医学杂志》2019年第17期2143-2147,共5页International Journal of Laboratory Medicine

摘　　要：结核病病原学确诊率低,缺乏细菌学证据易导致漏诊,错过治疗及预防的最佳时机,并造成严重的连锁反应。结核感染T细胞检测(T-SPOT.TB)试验是结核病辅助诊断的一种免疫学方法,目前可以用于潜伏性结核感染的诊断及活动性结核感染的辅助诊断,但在结核病高流行及低流行地区的诊断价值及应用尚存在争议。本文综述了T-SPOT.TB对结核高流行地区的菌阴性结核病、免疫缺陷结核病患者群的应用价值、影响因素及临界值判读。The rate of etiological diagnosis of tuberculosis is low.Lack of bacteriological evidence can easily lead to missed diagnosis,miss the best opportunity of treatment and prevention,and cause serious chain reaction.T-cell detection of tuberculosis infection (T-SPOT.TB) is an immunological method for assistant diagnosis of tuberculosis.It can be used for diagnosis of latent tuberculosis infection and assistant diagnosis of active tuberculosis infection.However,the diagnostic value and application of T-SPOT.TB in high and low prevalence areas of tuberculosis are still controversial.This paper reviews the application value,influencing factors and critical value of T-SPOT.TB in the treatment of bacterial-negative tuberculosis and immunodeficiency tuberculosis in high-prevalence areas.

关 键 词：结核感染T细胞检测 结核 菌阴性结核病 免疫缺陷结核病 

分 类 号：R52[医药卫生—内科学]