汉代至民国著名医家治疗喘证方剂用药规律的数据挖掘研究  

Data Mining Research on the Rule of Drugs Used in the Treatment of Asthma Syndrome by Famous Doctors from Han Dynasty to the Republic of China

作　　者：周建国 丁宇坤 何庆勇[3] 郭建波 王辉 但文超 覃堃 代爽 Zhou Jianguo;Ding Yukun;He Qingyong;Guo Jianbo;Wang Hui;Dan Wenchao;Qin Kun;Dai Shuang(Beijing Youjian Medical Investment Management Co.,Ltd.,Beijing 100025,China;Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]北京优健医疗投资管理有限公司,北京100025 [2]北京中医药大学研究生院,北京100029 [3]中国中医科学院广安门医院,北京100053

出　　处：《世界中医药》2019年第8期2033-2037,共5页World Chinese Medicine

基　　金：国家自然科学基金项目(81202803);北京市科技专项(Z181100006218035);中央本级重大增减支项目(2060302)

摘　　要：目的:探讨汉代至民国著名医家治疗喘证方剂的用药规律。方法:从医学典籍中共获得119条方剂,录入数据库并借助“中医辅助传承系统(V2.5)”对证候、单药、对药、角药频次等进行深度研究。结果:喘证最常见证候为:痰热郁肺证,痰浊阻肺证,肺气虚耗证;出现最多的药物是:甘草,杏仁,陈皮;出现最多的对药是:麻黄-杏仁,半夏-陈皮,陈皮-甘草;出现最多的角药是:甘草-麻黄-杏仁,半夏-陈皮-甘草,半夏-陈皮-茯苓;核心药物是陈皮,半夏,生姜,甘草,麻黄,杏仁;候选处方优选为竹茹-升麻-生地黄-玄参等。结论:喘证证候优先以痰热郁肺证,痰浊阻肺证为适应证;药物使用可优选甘草,杏仁;对药可优选麻黄-杏仁,半夏-陈皮;角药优选麻黄-杏仁-甘草,半夏-陈皮-甘草;核心药物为麻黄,杏仁,陈皮,半夏,生姜,甘草;候选药物可优选竹茹-升麻-生地黄-玄参等药物。Objective: To study prescription regularity on asthma symptom treatment by famous traditional Chinese medicine(TCM)doctors from the Han Dynasty to the Republic of China. Methods: A total of 119 prescriptions were obtained from medical books,and were entered into the database.The syndromes,single drugs,pairs of drugs and frequency of horn medicines were studied in depth with the help of “Chinese medicine auxiliary inheritance system(V2.5)”. Results: The most common syndromes of asthma were phlegm heat depressing the lung,phlegm turbid obstructing the lung,lung qi deficiency.The most common drugs were Radix Glycyrrhizae,Semen Armeniacae Amarum and Pericarpium Citri Reticulatae.The most commonly used drug pairs were Herba Ephedrae-Armeniacae Amarum,Rhizoma Pinelliae-Pericarpium Citri Reticulatae,Pericarpium Citri Reticulatae-Radix Glycyrrhizae.The most common triangle medicines were Radix Glycyrrhizae-Herba Ephedrae-Armeniacae Amarum,Rhizoma Pinelliae-Pericarpium Citri Reticulatae-Radix Glycyrrhizae,Rhizoma Pinelliae-Pericarpium Citri Reticulatae-Poria;the core medicines were Pericarpium Citri Reticulatae,Rhizoma Pinelliae,Rhizoma Zingiberis Recens,Radix Glycyrrhizae,Herba Ephedrae,Armeniacae Amarum;the best candidate prescription was Caulis Bambusae in Taenia,rhizoma-Rhizoma Cimicifugae-Radix Rehmanniae Recens-Radix Scrophulariae. Conclusion: 1)The syndromes of asthma syndrome are preferential for phlegm heat depressing the lung syndrome,phlegm turbid obstructing the lung syndrome as indications. 2)Radix Glycyrrhizae and Semen Armeniacae Amarum may be preferred for drug use. 3)Paired drugs may be preferred for Herba Ephedrae-Armeniacae Amarum,Rhizoma Pinelliae-Pericarpium Citri Reticulatae. 4)Triagle medicines may be preferred for Radix Glycyrrhizae-Herba Ephedrae-Armeniacae Amarum,Rhizoma Pinelliae-Pericarpium Citri Reticulatae-Radix Glycyrrhizae. 5)The core drugs are Herba Ephedrae,Armeniacae Amarum,Pericarpium Citri Reticulatae,Rhizoma Pinelliae,Rhizoma Zingiberis Recens,Radix Glycyrrhizae. 6)The candidate p

关 键 词：喘证 数据挖掘 中医辅助传承系统 关联规则 核心组合 复杂网络 学术思想 新药研究 

分 类 号：R289.9[医药卫生—方剂学]