证候与年龄对冠心病患者自主神经功能的影响  

Effects of Syndrome and Age on Autonomic Nervous Function in Patients with Coronary Heart Disease

作　　者：翟军鹏[1] 张大炜[1] 李方洁[2] Zhai Junpeng;Zhang Dawei;Li Fangjie(Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China;Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]中国中医科学院望京医院,北京100102

出　　处：《世界中医药》2019年第8期2213-2216,共4页World Chinese Medicine

基　　金：国家自然科学基金项目(30873216);北京市自然科学基金资助项目(7112148)

摘　　要：目的:探讨中医虚实证候、年龄因素对冠心病患者自主神经功能的影响。方法:选取2014年10月至2017年6月在首都医科大学附属北京中医医院、中国中医科学院望京医院心内科门诊及住院的冠心病患者150例作为研究对象。在中医学虚实辨证理论基础上把患者分为虚证组、实证组以及虚实夹杂证组;再根据WHO年龄分段标准将患者分为青年组、中年组、低龄老年组、高龄老年组;采集患者心率变异性(HRV)时域、频域指标,对不同年龄组及证候患者的HRV指标进行多元线性逐步回归分析,评价证候及年龄对HRV的影响。结果:HRV指标SDNN与年龄呈负相关,RMSSD、TP、LF、HF与年龄、虚实证候呈负相关。结论:中医证候与年龄对自主神经功能均有影响,随着由实到虚转化以及年龄增长,患者自主神经功能逐渐降低。Objective: To explore the effects of deficiency and excess syndromes in traditional Chinese medicine(TCM)and age factors on autonomic nervous function in patients with coronary heart disease. Methods: From October 2014 to June 2017,150 patients with coronary heart disease(CHD)were selected as research objects from the outpatient and inpatient department of cardiology in Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University and Wangjing Hospital of China Academy of Chinese Medical Sciences.On the basis of the theory of deficiency and excess syndrome differentiation in TCM,the patients were divided into deficiency syndrome group,excess syndrome group and deficiency-excess complex syndrome group.Then the patients were divided into youth group,middle-aged group,young elderly group and elderly group according to the WHO age subsection standard.Heart rate variability(HRV)time domain and frequency domain indexes of patients were collected,and the HRV indexes of different age and syndrome groups of patients were analyzed by multiple linear stepwise regression analysis to evaluate the influence of syndrome and age on HRV. Results: The HRV index SDNN was negatively correlated with age,and RMSSD,TP,LF and HF were negatively correlated with age and syndromes of deficiency and excess. Conclusion: Both TCM syndromes and age have effects on autonomic nervous function.With the syndrome transformation from excess to deficiency and the increase of age,the autonomic nervous function of the patients decreases gradually.

关 键 词：虚实证候 年龄 冠心病 自主神经 心率变异性 动态心电图 时域 频域 多元回归分析 

分 类 号：R256.22[医药卫生—中医内科学]