阿霉素在羧基化纳米金刚石表面的负载与释放性能研究  

Loading of Doxorubicin on Surface-Carboxylated Nanodiamond and Its Release Performance

作　　者：朱华敏 许向阳[1,2] 邵诗宇 胡金宇 迟伶俐 刘艳茹 于美苓 ZHU Hua-min;XU Xiang-yang;SHAO Shi-yu;HU Jin-yu;CHI Ling-li;LIU Yan-ru;YU Mei-ling(School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, Hunan, China;Key Laboratory of Mineral Materials and Application of Hunan Province, Central South University, Changsha 410083, Hunan, China)

机构地区：[1]中南大学资源加工与生物工程学院,湖南长沙410083 [2]矿物材料及其应用湖南省重点实验室,湖南长沙410083

出　　处：《矿冶工程》2019年第4期131-135,共5页Mining and Metallurgical Engineering

基　　金：矿物材料及其应用湖南省重点实验室开放课题(MMA201701)

摘　　要：利用高温氧化法实现纳米金刚石表面羧基化,以提高其对阿霉素药物的负载率。通过考查高温氧化条件、药物浓度、溶液pH值等因素对其载药效果的影响规律,得出最佳载药条件,制备了负载量为425μg/mg的纳米金刚石-阿霉素体系。探索了不同pH环境下该载药体系的药物释放规律,结果表明,羧基化纳米金刚石负载阿霉素后,可高效释药,最高释放率可达91%,说明纳米金刚石在改善药效发挥、降低药量、减少毒副作用等方面具有巨大潜力。High temperature oxidation approach was introduced to obtain a surface-carboxylated nanodiamond(ND), so as to benefit the loading of doxorubicin(DOX) thereon. The influences of oxidation parameters, drug concentration and solution pH value on drug loading behavior were investigated. ND-DOX system with a loading capacity of 425 μg/mg was prepared under the optimal conditions. Subsequently, the release performance of the loaded DOX under different pH conditions was studied. It is shown that carboxylated ND loaded with DOX can lead to a high-efficient drug release with the highest release rate attaining 91%, indicating that the ND carrier may have an application potential in improving drug efficacy, reducing drug dosage and minimizing drug toxicity.

关 键 词：纳米金刚石 高温氧化 羧基化 阿霉素 药物负载 药物释放 

分 类 号：TB321[一般工业技术—材料科学与工程]