一种基于主客体识别的长效无刺激驱避剂  

A Long-Lasting and No Skin Irritation Mosquito Repellent Based on Host-Guest Recognition

作　　者：吴迪[1] 张小勤 侯君波 张晟[1] 李帮经[2] Di Wu;XiaoqinZhan;Junbo Hou;Sheng Zhang;Bangjing Li(Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu 610062,China;Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China)

机构地区：[1]四川大学高分子研究所高分子材料工程国家重点实验室,四川成都610065 [2]中国科学院成都生物研究所,四川成都610041

出　　处：《高分子材料科学与工程》2019年第8期144-149,158,共7页Polymer Materials Science & Engineering

基　　金：高分子材料工程国家重点实验室自主课题

摘　　要：蚊虫是多种传染病的传播媒介,并且蚊虫的叮咬常常使人难以忍受,但目前的驱蚊产品或多或少均对人体有毒性及刺激性作用,人类直接接触后有一定的危害性。文中制备了一种长效且无刺激的驱避剂,利用γ-环糊精(γ-CD)与乙基丁酰基氨基丙酸乙酯(BAAPE)的包合作用,达到缓慢释放和稳定驱避的目的。研究表明,当BAAPE与γ-CD形成包合物后,对皮肤的刺激性下降,储藏稳定性增加,释放明显减缓,可长效驱蚊。涂抹7h后,包合物的驱蚊效果为市售花露水的数倍以上。Mosquitoes are the vector of many infectious diseases and mosquito bites are often unbearable.Most mosquito repellent products are toxic and irritating to human body,and human beings have a certain degree of harm after direct contacting with them.In this paper,a long-lasting and low irritation mosquito repellent was prepared by the formation of theγ-cyclodextrin(γ-CD)/ethyl butylacetylaminopropionate(BAAPE)inclusion complex.The results show that the toxicity of mosquito repellents reduces,the store stability increases,and the release rate of BAAPE decreases significantly after the formation of the inclusion complex.The mosquito repellent efficiency ofγ-CD/BAAPE is over several times better than that of commercial products(floral water).

关 键 词：Γ-环糊精 驱避剂 主客体识别 

分 类 号：O636.12[理学—高分子化学]