赣州市人群高同型半胱氨酸的影响因素研究  

The study of environmental factors for hyperhomocysteinemia in the population of Ganzhou

作　　者：江丽霞[1] 董明华 施少华[1] 张慧娟 李舒梅 夏宇 曹娟[1] JANG Li-xia;DONG Ming-hua;SHI Shao-hua;ZHANG Hui-juan;LI Shu-mei;XIA Yu;CAO Juan(Gannan Medical University The First Affiliated Hospital, Ganzhou, Jangxi 341000)

机构地区：[1]赣南医学院第一附属医院

出　　处：《赣南医学院学报》2019年第8期762-765,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金课题(No:81360445;No:81550045);江西省卫生厅项目(No:20155404)

摘　　要：目的:分析赣州市人群Hcy水平和分布情况,了解HHcy的环境影响因素,为今后卫生决策和制定Hcy群体干预措施提供科学依据,帮助政府制定科学合理的环境政策。方法:对赣州市人群进行随机分层抽样的3 886例成人采用酶法测定血Hcy水平,利用SPSS 17.0软件分别对HHcy的检出率及Hcy水平进行统计学分析,并采用条件Logistic回归模型对环境因素进行单因素和多因素分析,计算相应的OR值,筛选出最可能的危险因素。结果:3 886例研究对象中Hcy水平升高的总检出率为39.68%,其中男性为49.61%,女性为24.12%,男性高于女性,两组间比较差异有统计学意义(χ2=272.8, P<0.001)。经单因素Logistic条件回归分析,发现吸烟、年龄、不安全饮酒等是HHcy的主要危险因素,蛋类、豆类及豆制品摄入充足是HHcy的保护因素;对组间差异有统计学意义的自变量再做多因素条件Logistic条件回归分析,发现吸烟、不安全饮酒是HHcy的危险因素,豆类及其制品摄入充足是HHcy的保护因素。结论:赣州市人群Hcy水平均较高,HHcy检出率已占有较高的比例,可能与地区有关,也可能与赣州市人群主要为客家人群有关,或是与客家人群的遗传易感性有关。吸烟是高Hcy的危险因素,提示应尽早对高Hcy血症的人群进行干预,及时给予叶酸、维生素B6、维生素B12等进行干预,以降低心脑血管疾病的风险。Objective: Studying the population distribution of serum Hcy levels in GanZhou city and finding out the environmental influence factors of HHcy, so as to provide the evidence for future health decision-making and establish the intervention strategies on people with HHcy, and help the government formulate effective scheme to counter the disease of HHcy. Methods: The serum Hcy levels of 3 886 adult residents which were selected by stratified random cluster sampling in GanZhou city were tested by enzyme assay, the positive rate of HHcy and Hcy levels were statistically analyzed by SPSS 22.0 software, and the environmental influence factors were analyzed by the univariate and multivariate conditional logistic regression model, the corresponding OR values were calculated and then the most feasible risk factors were screened out. Results: The total positive rate of HHcy in 3 886 subjects was 39.68%, in which the positive rate of HHcy in males was 49.61% and the females was 24.12%, the positive rate of HHcy in males was higher than that in females, and there was a significant difference between genders. Smoking, age and unsafe drinking were found to be the main risk factors of HHcy through the univariate logical regression analysis, and adequately intake of eggs, beans and soy products are the protective factors of HHcy;further applying multivariate logistic regression model method with data, the result show that smoking, unsafe drinking are HHcy risk factors, adequately intake beans and soy products are HHcy protective factors. Conclusions: The level of Hcy in adult residents of GanZhou city is high;the positive rate of HHcy has been to occupy a higher proportion. The possible factors contributing to these results lie in the district, lifestyle of Hakka race of Ganzhou residents as to as the genetic susceptibility of Hakka population. As smoking is the main risk factor for high Hcy, it is suggested that intervention should be carried out as early as possible for people with high Hcy level, and folic acid, vitamin B6 an

关 键 词：HCY 高同型半胱氨酸血症 影响因素 

分 类 号：R195.4[医药卫生—卫生统计学]