手性脯氨醇类咪唑配体的制备  

The Synthesis of Chiral Imidazole Ligands Based on Chiral L-Prolinol

作　　者：霍艳敏[1] 孙兆峰 刘燕柯 姚清侠 龚树文[1] 段文增[1] HUO Yan-min;SUN Zhao-feng;LIU Yan-ke;YAO Qing-xia;GONG Shu-wen;DUAN Wen-zeng(Institute of Functional Organic Molecules and Materials,School of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252059,China)

机构地区：[1]聊城大学化学化工学院功能有机分子与材料研究所

出　　处：《聊城大学学报（自然科学版）》2019年第6期59-65,共7页Journal of Liaocheng University:Natural Science Edition

基　　金：国家自然科学基金项目（21801108）;山东省自然科学基金项目（ZR2017MB052,ZR2014BQ035,ZR2017MB060）;聊城大学博士科研启动基金资助

摘　　要：以N-Boc-L-脯氨醇(Boc:tert-butoxycarbonyl)为原料,设计合成了三种手性氮杂环卡宾前体:手性1-(3,5-苯二甲酸甲酯甲基)-3-(2-N-Boc-吡咯甲基)咪唑溴化盐,手性1-(3,5-苯二甲酸甲基)-3-(2-吡咯甲基)咪唑溴化盐和1,3-二苄基双(2-N-Boc-吡咯甲基)二咪唑溴化盐.通过核磁共振谱图对三种氮杂环卡宾前体进行了表征,同时对其氮杂环卡宾钯配合物的合成进行了研究.Using N-Boc-L-prolinol as material,we synthesized three chiral NHC precursors:chiral 1-(dimethyl-3,5-benzenedicarboxylate)-3-(2-N-Boc-pyrrolidinylmethyl)imidazolium bromide,chiral 1-(1,3-phthalicacid)-3-(2-pyrrolidinylmethyl)imidazolium bromide and 1,3-dibenzyl-di(2-N-Boc-pyrrolidinylmethyl)diimidazolium bromide.These ligands were all characterized by 1H NMR,13C NMR and then the preparing of NHC-Pd were also explored.

关 键 词：L-(+)-脯氨醇 咪唑盐 NHC-Pd. 

分 类 号：O626.13[理学—有机化学]