气管瘢痕狭窄动物模型的建立和病理学研究  

Ananimal Model and Pathological Research of Tracheal Stenosis

作　　者：汤苏成[1] 王跃建[1] 朱肇峰[1] TANG Su-cheng;WANG Yue-jian;ZHU Zao-feng(Department of Otolaryngology-Head and Neck Surgery, the First People’s Hospital of Foshan,Foshan 528000, China)

机构地区：[1]佛山市第一人民医院咽喉头颈外科

出　　处：《中国医药指南》2019年第22期3-4,共2页Guide of China Medicine

基　　金：组织工程气管上皮联合脱细胞真皮基质治疗气管瘢痕狭窄的实验研究（2016年佛山市自筹经费类科技计划项目（医学类科技攻关），项目编号55）

摘　　要：目的建立犬气管瘢痕狭窄的动物实验模型,观察其气管瘢痕形成的病理学过程,探讨气管瘢痕的形成机制。方法 6支成年比格犬,行颈部气管切开+气管前壁黏膜刮除术,刮除3 cm长气管管腔前1/2黏膜,创面裸露。建立气管瘢痕狭窄的动物模型,术后1周、2周、1个月、2个月、4个月、6个月麻醉后观察瘢痕的形成过程,行常规病理及免疫组化和透视电镜观察研究瘢痕的病理学变化和特征。结果6支动物均成活到预期的时间,气管瘢痕形成并逐渐狭窄,动物模型成功建立。结论我们成功建立了犬气管瘢痕动物模型,并初步研究了瘢痕的病理学特点,为下一步深层次的瘢痕形成机制和治疗的研究奠定了基础。Objective Design ananimal model of tracheal stenosis with Beagle dogs,To observe the process of tracheal mucosal scar formation. Methods For 6 beagle dogs, made an animal modelof tracheal stenosis, Observing the recovery of the wound, the arrangement and composition of extracellular matrix and fibroblast by pathologicalexamination. Results The animal model wassucsessful builted, the pathological feature of the tracheal mucosal scar was the anabolic metabolism of extracellular matrix. Conclusions Ouranimal modelwas successfully established , in this model, we demonstrate the pathological mechanism of the tracheal scar, and lay the foundationfor the foward research.

关 键 词：气管狭窄 增生性瘢痕 动物模型 

分 类 号：R562.12[医药卫生—呼吸系统]