氯吡格雷联合阿司匹林肠溶片对急性心肌梗死的应用价值分析  

Analyzed the Application Value of Clopidogrel Combined with Aspirin Enteric-coated Tablets in Acute Myocardial Infarction

作　　者：谢伟山[1] 伍运辉 吴向前[1] 骆强 XIE Wei-shan;WU Yun-hui;WU Xiang-qian;LUO Qiang(Department of Emergency, Houjie Hospital of Dongguan, Dongguan 523000, China)

机构地区：[1]东莞市厚街医院急诊科

出　　处：《中国医药指南》2019年第22期93-94,共2页Guide of China Medicine

摘　　要：目的急性心肌梗死(AMI)患者应用氯吡格雷与阿司匹林肠溶片联合治疗效果观察。方法选取2017年11月至2018年11月本院诊治110例急性心肌梗死患者资料,随机分成两组,对照组予阿司匹林肠溶片,研究组予氯吡格雷与阿司匹林肠溶片联合治疗方案,分析两组患者临床疗效、心功能指标及再闭塞情况。结果治疗后,研究组显效35例,有效19例,无效1例,对照组依次为27例、19例、9例,研究组总有效54例(98.18%)比对照组46例(93.64%)高,比较差异具有统计学意义(P<0.05);治疗后两组心功能指标均改善,且研究组APTT(36.96±1.23)s、PT(11.13±0.76)s及PLT(205.03±6.53)×10~9指标,均比对照组优,比较差异具有统计学意义(P<0.05);研究组血管再次闭塞36.36%比对照组低,比较差异具有统计学意义(P<0.05)。结论急性心肌梗死患者应用氯吡格雷与阿司匹林肠溶片联合治疗,能提高临床效果,并改善患者心功能指标,降低其预后血管再次闭塞情况,具一定临床应用价值。Objective To observe the effect of clopidogrel combined with aspirin enteric-coated tablets in patients with acute myocardial infarction(AMI). Methods The data of 110 patients with acute myocardial infarction were selected from November 2017 to November 2018. They were randomly divided into two groups.The control group was given aspirin enteric-coated tablets.The study group was treated with clopidogrel and aspirin enteric-coated tablets. The clinical efficacy, cardiac function index and reocclusion of the two groups were analyzed. Results After treatment, the study group was effectivety in 35 cases, effective in 19 cases, and ineffective in 1 case. The control group was 27 cases, 19 cases, and 9 cases. The total effective rate of the study group was 54(98.18%), which was higher than the control group 46(93.64%), the difference was statistically significant(P<0.05). After treatment, the cardiac function indexes of both groups has improved, and the APTT(36.96±1.23)s, PT(11.13±0.76)s and PLT(205.03±6.53)×10~9 indicators were better than the control group, and the difference was statistically significant(P<0.05). The vascular occlusion of the study group was 36.36%, which lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion The combination of clopidogrel and aspirin enteric-coated tablets in patients with acute myocardial infarction could improve the clinical effect,improve the cardiac function of patients,and reduce the prognosis of revascularization.It has certain clinical application value.

关 键 词：急性 心肌梗死 氯吡格雷 阿司匹林 心功能 临床疗效 

分 类 号：R542.22[医药卫生—心血管疾病]