4-甲基-3-硫代氨基脲型钌配合物的合成和性质研究  

Synthesis and Property of 4-Methyl-3-thiosemicarbazone Ruthenium Complex

作　　者：李培源 周泉 贾智若 Li Peiyuan;Zhou Quan;Jia Zhiruo(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530001,China;College of Chemistry and Materials Science,Nanning Normal University,Nanning 530001,China)

机构地区：[1]广西中医药大学,药学院,广西南宁530001 [2]南宁师范大学化学与材料科学学院,广西南宁530001

出　　处：《山东化工》2019年第16期5-6,共2页Shandong Chemical Industry

基　　金：广西自然科学基金(2017GXNSFAA198335);壮瑶药协同创新中心(桂教科研[2013]20号);广西壮瑶药重点实验室(桂科基字[2014]32号);广西重点学科壮药学(桂教科研[2013]16号);广西一流学科中药学(民族药学)(桂教科研[2018]12号);广西中医药大学校级课题(2017JQ001);广西中医药大学中药学优势学科建设专项课题(ZYX2017003)

摘　　要：钌配合物由于其的高效、低毒的特点,可有效克服铂金属配合物副作用大、对癌细胞缺少选择性等缺点,而成为研究热点。本论文采用邻甲氧基苯甲醛和4-甲基-3-硫代氨基脲反应制备邻甲氧基苯甲醛缩4-甲基-3-硫代氨基脲,将邻甲氧基苯甲醛缩4-甲基-3-硫代氨基脲作为配体与[Ru(p-cymene)Cl2]2反应制备邻甲氧基苯甲醛缩4-甲基-3-硫代氨基脲配合物,并研究其性质。Ruthenium complex has been hot research topic for its high-efficiency and low toxicity,which can overcome the side effects and low selectivity against cancer cells of platinum complex.In this paper,o-methoxy benzaldehyde and 4-methyl-3-thiosemicarbazone were chosen to get o-methoxy benzaldehyde 4-methyl-3- thiosemicarbazone,which further reacted with [Ru(p-cymene)Cl 2] 2 to produceo-methoxy benzaldehyde 4-methyl-3-thiosemicarbazone complex.The spectral quality of o-methoxy benzaldehyde 4-methyl- 3-thiosemicarbazone complex was investigated.

关 键 词：氨基硫脲 苯甲醛 性质 

分 类 号：O62[理学—有机化学]