自身免疫性甲状腺疾病患者甲状腺自身抗体与纤维化四项联检的临床价值分析  

An Analysis on the Clinical Value of Thyroid Autoantibodies with Four Fibrosis Indexes in Patients with Autoimmune Thyroid Diseases

作　　者：吴兴勇[1] 徐洪林 刘越 姜敏[1] WU Xing-yong;XU Hong-lin;LIU Yue;JIANG Min(Nuclear Medicine Department,Chengdu Fifth People’s Hospital,Chengdu 610130,China)

机构地区：[1]成都市第五人民医院核医学科

出　　处：《标记免疫分析与临床》2019年第8期1329-1331,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨利用自身免疫性甲状腺疾病患者中,血清甲状腺过氧化物酶抗体(TPOAb)及甲状腺球蛋白抗体(TgAb)水平联合血清纤维化四项检测,评价甲状腺组织纤维化的临床价值分析。方法选取我院就诊的174例患者,甲状腺相关自身抗体异常增高作为病例组;选取在我院体检科健康体检者25例,甲状腺相关自身抗体均正常作为对照组。采用化学发光法测定TPOAb、TgAb;采用放射免疫法检测纤维化四项包括:血清层黏蛋白(LN)、血清透明质酸(HA)、血清Ⅲ型前胶原氨端肽(PⅢNP)、血清IV胶原(CIV)。采用SPSS 21.0软件进行方差分析(ANOV)和t检验;Pearson相关性分析TPOAb、TgAb分别与纤维化四项的关系。结果阳性组与对照组、超声影像不同表现组比较,纤维化指标水平差异无统计学意义;血清TPOAb、TGAb分别与PⅢNP、CIV、LN、HA进行相关性分析(P>0.05),呈显著无相关。结论甲状腺自身抗体异常患者,甲状腺功能正常情况下,纤维化指标检测用于判断甲状腺纤维化的意义不大。Objective To assess the clinical value of evaluating thyroid fibrosis using serum thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)levels with four fibrosis indexes in patients with autoimmune thyroid diseases.Methods The case group consisted of 174 patients visited our hospital due to abnormally increased thyroid autoantibodies.The control group consisted of 25 healthy examinees with normal thyroid autoantibodies who visited the physical examination department of our hospital.TPOAb and TgAb levels were determined using the chemiluminiscence method.The radioimmunoassay was utilized to test four fibrosis indexes in serum,including laminin(LN),hyaluronic acid(HA),Procollagen Ⅲ N-Terminal Propeptide(PⅢNP)and collagen IV(CIV).SPSS21.0 software was adopted for the analysis of variance(ANOV)and t test.Pearson correlation test was used to analyze the correlation of TPOAb and TgAb levels with four fibrosis indexes.Results Compared the results of the positive group with the control group and the group of different ultrasound images,fibrosis indexes showed no significant differences.Correlation analysis of serum TPOAb and TGAb levels with PⅢNP,CIV,LN and HA,respectively,showed no significant correlations.Conclusion For patients with abnormal thyroid autoantibodies,with the normal thyroid functions,the detection of fibrosis indexes is not informative for the diagnosis of thyroid fibrosis.

关 键 词：自身免疫性甲状腺疾病 纤维化标志物 甲状腺自身抗体 

分 类 号：R581[医药卫生—内分泌]