家庭雾化在毛细支气管炎治疗中的应用价值研究  

Family Aerosol Inhalation in the Treatment of Bronchiolitis

作　　者：李瑶[1] 谢露[1] 马秀娟 刘渝[1] Li Yao;Xie Lu;Ma Xiujuan;Liu Yu(Kunming City Maternal and Child Health Hospital,Yunnan Kunming 650031,China)

机构地区：[1]昆明市妇幼保健院

出　　处：《儿科药学杂志》2019年第9期27-30,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨家庭雾化治疗婴幼儿毛细支气管炎的临床疗效及预后。方法:148例婴幼儿毛细支气管炎患者分为两组,观察组(79例)采用家庭雾化治疗,对照组(69例)为住院治疗,两组患儿均采用相同的综合治疗方法,包括呼吸道管理、止咳、化痰、口服孟鲁司特28 d等对症治疗,抗病毒(雾化吸入重组人干扰素a-1b)、雾化吸入糖皮质激素(布地奈德)和β2受体激动剂(特布他林),2次/天,在治疗前5 d内每天复诊、评估病情,连续用药7 d。观察两组患儿临床症状改善情况及临床疗效,1个月后随访肺功能。结果:观察组临床总有效率(92. 4%)高于对照组(81. 2%),两组患儿比较差异有统计学意义(χ^2=4. 163,P <0. 05);全身激素使用率、抗菌素使用率、静脉输液率、总医疗费用两组患儿比较差异均有统计学意义(P<0. 01);1个月后随访肺功能,潮气量两组患儿比较差异无统计学意义(t=1. 433,P>0. 05),达峰时间、达峰容积两组患儿比较差异均有统计学意义(P<0. 05)。结论:轻症毛细支气管炎,可采用家庭雾化的方式治疗,有利于快速控制患儿症状,取得了良好的社会效益和经济效益。Objective: To probe into the clinical efficacy and prognosis of family aerosol inhalation in the treatment of bronchiolitis. Methods: A total of 148 infants with bronchiolitis were enrolled, the observation group (n=79) was treated with family aerosol inhalation, while the control group (n=69) was hospitalized. Both groups were treated with the same comprehensive treatment methods, including respiratory tract management, cough relieving, phlegm resolving, oral montelulast for 28 d and other symptomatic treatment, antiviral (aerosol inhalation of recombinant human interferon α-1b), aerosol inhalation of corticosteroid (budesonide) and β2 receptor agonist (terbutaline), 2 times/d. Within 5 d before treatment, the patient was re-examined and evaluated every day. All patients received continuous medication for 7 d. The clinical symptoms and efficacy of two groups were observed. The lung function was followed up after 1 month. Results: The total effective rate of the observation group (92.4%) was better than that of the control group (81.2%), and the difference was statistically significant (χ^2=4.163, P<0.05). There were statistically significant differences in the utilization rate of systemic hormones, antibiotics, intravenous infusion rate and total medical expenses between two groups (P<0.01). There was no significant difference in tidal volume between two groups after 1 month (t=1.433, P>0.05). There were significant differences between two groups in peak time and peak volume (P<0.05). Conclusion: Mild bronchiolitis can be treated by family aerosol inhalation, which is beneficial to quickly control the symptoms of children, and achieve better social benefits and economic benefits.

关 键 词：家庭雾化 轻症 毛细支气管炎 

分 类 号：R725.6[医药卫生—儿科]