化纤胶囊Ⅱ对气虚血瘀型脓毒症患者血清降钙素原白细胞计数及C-反应蛋白的影响  

Effects of Huaxian capsule Ⅱ on PCT, WBC and CRP in patients with sepsis due to Qi deficiency and blood stasis syndrome

作　　者：梁群[1] 张天宇[2] 朱永志[1] 谢礼翔 孙德阳 杨洋[2] Liang Qun;Zhang Tian-yu;Zhu Yong-zhi;Xie Li-xiang;Sun De-yang;Yang Yang(Department of Critical Care Medicine, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中国急救医学》2019年第8期784-788,共5页Chinese Journal of Critical Care Medicine

基　　金：国家自然科学基金项目(81774276);哈尔滨市应用技术研究与开发项目(2017RAXXJ037);黑龙江中医药大学科研基金项目(2017XY03);双一流及优势特色学科建设项目(051022).

摘　　要：目的探讨化纤胶囊Ⅱ对气虚血瘀型脓毒症患者血清降钙素原(PCT)、白细胞计数(WBC)及C-反应蛋白(CRP)的影响.方法按照随机对照试验方法将2015年1月至2016年12月收入黑龙江中医药大学附属第一医院重症医学科(ICU)的60例中医症状分型符合气虚血瘀证的脓毒症患者随机分成两组,即试验组和对照组.对照组按脓毒症常规治疗方法给予对因、对症治疗;试验组在对照组的治疗基础上加用化纤胶囊Ⅱ水煎剂(鼻饲给药).两组患者治疗第7天后取外周静脉血,观察化纤胶囊Ⅱ对气虚血瘀型脓毒症患者血清PCT、WBC及CRP的影响.结果治疗后试验组血清PCT从(4.27±0.56)μg/L降至(1.17±0.25)μg/L,血WBC从(20.19 ±2.63)×10^9/L降至(12.09±4-1.97)×10^9/L,CRP从(269.25±81.31)mg/L降至(14.18±7.43)mg/L,急性生理学及慢性健康状况Ⅱ(APACHEⅡ)评分由(29.23±2.91)分降至(19.87±2.03)分,其血清PCT、WBC、CRP与APACHEⅡ评分指标的下降程度明显大于对照组,差异有统计学意义(P<0.05).结论化纤胶囊Ⅱ能有效降低气虚血瘀型脓毒症患者的血清PCT、WBC、CRP水平及APACHEⅡ评分,能缓解脓毒症患者病情的进一步发展.Objective To investigate the effects of Huaxian capsule Ⅱ on procalcitonin (PCT), white blood cell count (WBC) and C-reactive protein (CRP) in patients with sepsis due to Qi deficiency and blood stasis syndrome. Methods Sixty cases of patients with sepsis and the TCM symptom type with Qi deficiency and blood stasis syndrome from January 2015 to December 2016 in our hospital ICU ward were randomly divided into two groups according to randomized controlled trials, namely the experimental group and the control group. The control group was given symptomatic treatment according to the conventional treatment of sepsis. The experimental group was treated with the Huaxian capsule Ⅱ water decoction on the basis of the treatment of the control group. Two groups of patients received peripheral vein blood sampling after 7 days, and the influence of Huaxian capsule Ⅱ on PCT, WBC and CRP were observed in patients with Qi deficiency and blood stasis type of sepsis. Results After treatment, PCT in the experimental group decreased from (4.27±0.56)μg/L to (1. 17 ±0. 25)μg/L, WBC from (20. 19 ± 2.63)×10^9/L to (12.09 ±1.97)×10^9/L, CRP from (269. 25 ± 81.31) mg/L to (14. 18±7.43) mg/L, and APACHE Ⅱ score from (29. 23 ±2.91) to (19. 87 ±2.03). The decrease of PCT, WBC, CRP and APACHE Ⅱ scores was significantly greater than that of the control group (P < 0. 05). Conclusion Huaxian capsule Ⅱ can reduce the levels of PCT, WBC, CRP, APACHE Ⅱ score in patients with sepsis, and alleviate the further development of sepsis.

关 键 词：化纤胶囊Ⅱ 气虚血瘀型 脓毒症 降钙素原(PCT) 白细胞计数(WBC) C-反应蛋白(CRP) 

分 类 号：R459.7[医药卫生—急诊医学]